Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. - Archive ouverte HAL Access content directly
Journal Articles Molecular and Cellular Biology Year : 2005

Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin.

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Abstract

In the cochlea, the mammalian auditory organ, fibrocytes of the mesenchymal nonsensory regions play important roles in cochlear physiology, including the maintenance of ionic and hydric components in the endolymph. Occurrence of human deafness in fibrocyte alterations underlines their critical roles in auditory function. We recently described a novel gene, Otos, which encodes otospiralin, a small protein of unknown function that is produced by the fibrocytes of the cochlea and vestibule. We now have generated mice with deletion of Otos and found that they show moderate deafness, with no frequency predominance. Histopathology revealed a degeneration of type II and IV fibrocytes, while hair cells and stria vascularis appeared normal. Together, these findings suggest that impairment of fibrocytes caused by the loss in otospiralin leads to abnormal cochlear physiology and auditory function. This moderate dysfunction may predispose to age-related hearing loss.

Dates and versions

inserm-00266032 , version 1 (20-03-2008)

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Benjamin Delprat, Jérôme Ruel, Matthieu J. Guitton, Ghyslaine Hamard, Marc Lenoir, et al.. Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin.. Molecular and Cellular Biology, 2005, 25 (2), pp.847-53. ⟨10.1128/MCB.25.2.847-853.2005⟩. ⟨inserm-00266032⟩
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