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Stimulation of the primary anti-HIV antibody response by IFN-{alpha} in patients with acute HIV-1 infection.

Abstract : Type I IFNs are needed for the production of antiviral antibodies in mice; whether they also stimulate primary antibody responses in vivo during human viral infections is unknown. This was assessed in patients acutely infected with HIV-1 and treated with IFN-alpha2b. Patients with acute HIV-1 infection were randomized to receive antiretroviral therapy alone (Group A, n=60) or combined for 14 weeks with pegylated-IFN-alpha2b (Group B, n=30). Emergence of anti-HIV antibodies was monitored during 32 weeks by Western blot (WB) analyses of serum samples. IFN-alpha2b treatment stimulated the production of anti-HIV antibodies. On Week 32, 19 weeks after the last IFN-alpha2b administration, there were 8.5 (6.5-10.0) HIV WB bands (median, interquartile range) in Group B and 7.0 (5.0-10.0) bands in Group A (P=0.054), and band intensities were stronger in Group B (P<0.05 for p18, p24, p34, p40, and p55 HIV antigens). IFN-alpha2b treatment also increased circulating concentrations of the B cell-activating factor of the TNF family (P<0.001) and ex vivo production of IL-12 (P<0.05), reflecting its effect on innate immune cells. Withdrawal of antiretroviral treatment on Week 36 resulted in a lower rebound of HIV replication in Group B than in Group A (P<0.05). Therefore, type I IFNs stimulate the emerging anti-HIV immune response in patients with acute HIV-1 infection, resulting in an improved control of HIV replication. Type I IFNs are thus critical in the development of efficient antiviral immune responses in humans, including the production of antiviral antibodies.
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Contributor : Evelyne Mouillet <>
Submitted on : Wednesday, March 12, 2008 - 3:26:33 PM
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Laura Adalid-Peralta, Véronique Godot, Céline Colin, Roman Krzysiek, Thi Tran, et al.. Stimulation of the primary anti-HIV antibody response by IFN-{alpha} in patients with acute HIV-1 infection.. Journal of Leukocyte Biology, Society for Leukocyte Biology, 2008, 83 (4), pp.1060-1067. ⟨10.1189/jlb.1007675⟩. ⟨inserm-00263595⟩



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