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In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors.

Abstract : We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, lopinavir, and darunavir are potent against wild-type HIV-2 isolates and should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors are less active against HIV-2 than against HIV-1.
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https://www.hal.inserm.fr/inserm-00263591
Contributor : Evelyne Mouillet <>
Submitted on : Wednesday, March 12, 2008 - 3:20:35 PM
Last modification on : Wednesday, August 19, 2020 - 11:58:38 AM
Long-term archiving on: : Friday, May 21, 2010 - 12:23:10 AM

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Delphine Desbois, Bénédicte Roquebert, Gilles Peytavin, Florence Damond, Gilles Collin, et al.. In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2008, 52 (4), pp.1545-1548. ⟨10.1128/AAC.01284-07⟩. ⟨inserm-00263591⟩

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