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Multi-state model for dementia, institutionalization and death

Daniel Commenges 1, * Pierre Joly 1
* Corresponding author
Abstract : We consider a multi-state model for jointly modeling dementia, institutionalization and death from data of cohort studies. Such a model could help understanding the relationships between dementia and institutionalization and also allow to make correct inferences when the initial sample of a cohort was selected as not living in institution. We consider the case where times of death and entrance in institution are known exactly while the clinical status of dementia is observed only at discrete time points. We give the likelihood in this setting and propose a penalized likelihood approach for estimating the transition intensities. A simulation study demonstrates that this non-parametric approach yields satisfactory results in this complex setting.
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Submitted on : Tuesday, November 10, 2009 - 3:52:48 PM
Last modification on : Wednesday, November 29, 2017 - 2:54:13 PM
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  • HAL Id : inserm-00262030, version 1



Daniel Commenges, Pierre Joly. Multi-state model for dementia, institutionalization and death. Communications in Statistics, 2004, 33 (6), pp.1315-1326. ⟨inserm-00262030⟩



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