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Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study.

Abstract : OBJECTIVE:: The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations. METHODS:: This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects. RESULTS:: An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0-19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8-5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years. CONCLUSIONS:: Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.
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Submitted on : Tuesday, March 4, 2008 - 5:01:17 PM
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Jean-François Ferrand, Sylvie Cénée, Pierre Laurent-Puig, Marie-Anne Loriot, Jean-Claude Trinchet, et al.. Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study.. Journal of Occupational & Environmental Medicine, 2008, 50 (2), pp.212-220. ⟨10.1097/JOM.0b013e31815d88e2⟩. ⟨inserm-00260676⟩



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