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[In vitro activity of ertapenem against strains isolated from diabetic foot infections.]

Abstract : OBJECTIVE: The authors had for aim to evaluate the in vitro activity of ertapenem against bacterial strains isolated from diabetic foot infections (DFI). METHODOLOGY: All diabetic patients hospitalized for a first episode of DFI (stages 2 to 4, according to the International Working Group of Diabetic Foot Classification) were selected in the N?s University hospital between January 2005 to December 2005. MICs were determined using both E-test((R)) strips and dilution methods on bacterial strains isolated from foot samples. RESULTS: Two hundred and fifty-two bacteria (154 Gram-positive cocci including 94 Staphylococcus aureus, 80 Gram-negative bacilli with 56 Enterobacteriaceae, and 18 anaerobes) were studied. Ertapenem was active against all Streptococcus spp., Enterobacteriaceae, anaerobes, and also against 89.8% of methicillin-susceptible S. aureus isolates. However, this antibiotic was active only against 31.5% of Staphylococcus epidermidis, 21.8% of Enterococcus faecalis, and 15.8% of Pseudomonas aeruginosa. CONCLUSION: Our results indicate that ertapenem may be a useful agent to treat patients suffering from DFI after bacterial identification.
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Contributor : Jean-Philippe Lavigne <>
Submitted on : Friday, February 22, 2008 - 4:08:13 PM
Last modification on : Friday, June 12, 2020 - 5:00:11 PM
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Albert Sotto, Xavier Lemaire, Nathalie Jourdan, Nicole Bouziges, Jean-Louis Richard, et al.. [In vitro activity of ertapenem against strains isolated from diabetic foot infections.]. Médecine et Maladies Infectieuses, Elsevier Masson, 2008, epub ahead of print. ⟨10.1016/j.medmal.2007.11.018⟩. ⟨inserm-00258593⟩

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