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[Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature]

Abstract : Cranberries (Vaccinium macrocarpon) have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Among cranberry compounds, a group of proanthocyanidins (PACs) with A-type linkages were isolated which exhibit bacterial anti-adhesion activity against uropathogenic Escherichia coli strains. These PAC inhibit P-fimbriae synthesis and induce a bacterial deformation. This activity was demonstrated on both antibiotic susceptible and resistant bacteria. This review focused on the last discoveries in the knowledge of cranberry effects.
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Contributor : Jean-Philippe Lavigne Connect in order to contact the contributor
Submitted on : Friday, February 22, 2008 - 3:38:48 PM
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Jean-Philippe Lavigne, G. Bourg, Henri Botto, Albert Sotto. [Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature]. Pathologie Biologie, Elsevier Masson, 2007, 55 (8-9), pp.460-4. ⟨10.1016/j.patbio.2007.07.005⟩. ⟨inserm-00258570⟩



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