P. Ridker, J. Buring, N. Cook, and N. Rifai, C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events: An 8-Year Follow-Up of 14 719 Initially Healthy American Women, Circulation, vol.107, issue.3, pp.391-397, 2003.
DOI : 10.1161/01.CIR.0000055014.62083.05

G. Hotamisligil, Inflammation and metabolic disorders, Nature, vol.314, issue.7121, pp.860-867, 2006.
DOI : 10.1038/nature05485

S. Hursting, N. Nunez, L. Varticovski, and C. Vinson, The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse, Cancer Research, vol.67, issue.6, pp.2391-2393, 2007.
DOI : 10.1158/0008-5472.CAN-06-4237

G. Hansson, Inflammation, Atherosclerosis, and Coronary Artery Disease, New England Journal of Medicine, vol.352, issue.16, pp.1685-1695, 2005.
DOI : 10.1056/NEJMra043430

D. Cottam, S. Mattar, E. Barinas-mitchell, G. Eid, L. Kuller et al., The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss, Obesity Surgery, vol.14, issue.5, pp.589-600, 2004.
DOI : 10.1381/096089204323093345

G. Ailhaud, Adipose tissue as an endocrine organ, International Journal of Obesity, vol.24, issue.2, pp.1-3, 2000.
DOI : 10.1038/sj.ijo.0801267

C. Lyon, R. Law, and W. Hsueh, Minireview: Adiposity, Inflammation, and Atherogenesis, Endocrinology, vol.144, issue.6, pp.2195-2200, 2003.
DOI : 10.1210/en.2003-0285

P. Havel, Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism, Diabetes, vol.53, issue.Supplement 1, pp.143-151, 2004.
DOI : 10.2337/diabetes.53.2007.S143

H. Xu, G. Barnes, Q. Yang, G. Tan, D. Yang et al., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, Journal of Clinical Investigation, vol.112, issue.12, pp.1821-1830, 2003.
DOI : 10.1172/JCI19451DS1

C. Curat, A. Miranville, C. Sengenes, M. Diehl, C. Tonus et al., From Blood Monocytes to Adipose Tissue-Resident Macrophages: Induction of Diapedesis by Human Mature Adipocytes, Diabetes, vol.53, issue.5, pp.1285-1292, 2004.
DOI : 10.2337/diabetes.53.5.1285

K. Clement, N. Viguerie, C. Poitou, C. Carette, V. Pelloux et al., Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects, The FASEB Journal, vol.18, issue.14, pp.1657-1669, 2004.
DOI : 10.1096/fj.04-2204com

S. Caspar-bauguil, B. Cousin, A. Galinier, C. Segafredo, M. Nibbelink et al., Adipose tissues as an ancestral immune organ: Site-specific change in obesity, FEBS Letters, vol.100, issue.17, pp.3487-3492, 2005.
DOI : 10.1016/j.febslet.2005.05.031

R. Cancello, C. Henegar, N. Viguerie, S. Taleb, C. Poitou et al., Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss, Diabetes, vol.54, issue.8, pp.2277-2286, 2005.
DOI : 10.2337/diabetes.54.8.2277

N. Viguerie, C. Poitou, R. Cancello, V. Stich, K. Clement et al., Transcriptomics applied to obesity and caloric restriction, Biochimie, vol.87, issue.1, pp.117-123, 2005.
DOI : 10.1016/j.biochi.2004.12.011

A. Barabasi and Z. Oltvai, Network biology: understanding the cell's functional organization, Nature Reviews Genetics, vol.5, issue.2, pp.101-113, 2004.
DOI : 10.1038/nrg1272

R. Guimera, N. Amaral, and L. , Functional cartography of complex metabolic networks, Nature, vol.220, issue.7028, pp.895-900, 2005.
DOI : 10.1038/35075138

D. Watts and S. Strogatz, Collective dynamics of 'small-world' networks, Nature, vol.393, issue.6684, pp.440-442, 1998.
DOI : 10.1038/30918

J. Dopazo, Functional Interpretation of Microarray Experiments, OMICS: A Journal of Integrative Biology, vol.10, issue.3, pp.398-410, 2006.
DOI : 10.1089/omi.2006.10.398

S. Taleb, D. Lacasa, J. Bastard, C. Poitou, R. Cancello et al., Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis, The FASEB Journal, vol.19, pp.1540-1542, 2005.
DOI : 10.1096/fj.05-3673fje

V. Tusher, R. Tibshirani, and G. Chu, Significance analysis of microarrays applied to the ionizing radiation response, Proceedings of the National Academy of Sciences, vol.98, issue.9, pp.5116-5121, 2001.
DOI : 10.1073/pnas.091062498

K. Taylor and R. Gallo, Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation, The FASEB Journal, vol.20, issue.1, pp.9-22, 2006.
DOI : 10.1096/fj.05-4682rev

N. Kawaguchi, C. Sundberg, M. Kveiborg, B. Moghadaszadeh, M. Asmar et al., ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating ??1 integrin function, Journal of Cell Science, vol.116, issue.19, pp.3893-3904, 2003.
DOI : 10.1242/jcs.00699

A. Prasse, D. Pechkovsky, G. Toews, W. Jungraithmayr, F. Kollert et al., A Vicious Circle of Alveolar Macrophages and Fibroblasts Perpetuates Pulmonary Fibrosis via CCL18, American Journal of Respiratory and Critical Care Medicine, vol.173, issue.7, pp.781-792, 2006.
DOI : 10.1164/rccm.200509-1518OC

T. Kong, H. Eltzschig, J. Karhausen, S. Colgan, and C. Shelley, Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of ??2 integrin gene expression, Proceedings of the National Academy of Sciences, vol.101, issue.28, pp.10440-10445, 2004.
DOI : 10.1073/pnas.0401339101

L. Fogelstrand, J. Hulthe, L. Hulten, O. Wiklund, and B. Fagerberg, Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance, Diabetologia, vol.144, issue.11, pp.1948-1952, 2004.
DOI : 10.1007/s00125-004-1553-x

L. Cabec, V. Carreno, S. Moisand, A. Bordier, and C. , Complement Receptor 3 (CD11b/CD18) Mediates Type I and Type II Phagocytosis During Nonopsonic and Opsonic Phagocytosis, Respectively, The Journal of Immunology, vol.169, issue.4, pp.2003-2009, 2002.
DOI : 10.4049/jimmunol.169.4.2003

URL : https://hal.archives-ouvertes.fr/hal-00178849

M. Sitkovsky and D. Lukashev, Regulation of immune cells by local-tissue oxygen tension: HIF1?? and adenosine receptors, Nature Reviews Immunology, vol.16, issue.9, pp.712-721, 2005.
DOI : 10.1242/jcs.00318

S. Chai and A. Ma, Interleukin-15 and the regulation of lymphoid homeostasis, Mol Immunol, vol.39, pp.537-544, 2002.

H. Do, A. Vasilescu, W. Carpentier, L. Meyer, G. Diop et al., Exhaustive Genotyping of the Interleukin???1 Family Genes and Associations with AIDS Progression in a French Cohort, The Journal of Infectious Diseases, vol.194, issue.11, pp.1492-1504, 2006.
DOI : 10.1086/508545

M. Richard, N. Thibault, P. Veilleux, R. Breton, and A. Beaulieu, The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents, Biochemical and Biophysical Research Communications, vol.310, issue.3, pp.767-773, 2003.
DOI : 10.1016/j.bbrc.2003.09.077

D. Acquisto, F. Merghani, A. Lecona, E. Rosignoli, G. Raza et al., Annexin-1 modulates T-cell activation and differentiation, Blood, vol.109, issue.3, pp.1095-1102, 2007.
DOI : 10.1182/blood-2006-05-022798

M. Yunta and P. Lazo, Apoptosis protection and survival signal by the CD53 tetraspanin antigen, Oncogene, vol.22, issue.8, pp.1219-1224, 2003.
DOI : 10.1038/sj.onc.1206183

G. Cook, C. Longhurst, S. Grgurevich, S. Cholera, J. Crossno et al., Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly, Blood, vol.100, issue.13, pp.4502-4511, 2002.
DOI : 10.1182/blood.V100.13.4502

L. Weaver, P. Pioli, K. Wardwell, S. Vogel, and P. Guyre, Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors, Journal of Leukocyte Biology, vol.81, issue.3, pp.663-671, 2007.
DOI : 10.1189/jlb.0706428

P. Philippidis, J. Mason, B. Evans, I. Nadra, K. Taylor et al., Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and After Cardiopulmonary Bypass Surgery, Circulation Research, vol.94, issue.1, pp.119-126, 2004.
DOI : 10.1161/01.RES.0000109414.78907.F9

Y. Son, J. Park, Y. Kang, J. Park, H. Choi et al., Heat Shock 70-kDa Protein 8 Isoform 1 Is Expressed on the Surface of Human Embryonic Stem Cells and Downregulated upon Differentiation, Stem Cells, vol.99, issue.10, pp.1502-1513, 2005.
DOI : 10.1634/stemcells.2004-0307

J. Kiang, Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury, Cell Research, vol.70, issue.6, pp.450-459, 2004.
DOI : 10.1038/sj.cr.7290247

M. Suter, V. Giusti, E. Heraief, F. Zysset, and J. Calmes, Laparoscopic Roux-en-Y gastric bypass, Surgical Endoscopy And Other Interventional Techniques, vol.17, issue.4, pp.603-609, 2003.
DOI : 10.1007/s00464-002-8952-1

D. Lacasa, S. Taleb, M. Keophiphath, A. Miranville, and K. Clement, Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes, Endocrinology, vol.148, issue.2, pp.868-877, 2007.
DOI : 10.1210/en.2006-0687

URL : https://hal.archives-ouvertes.fr/inserm-00126603

R. Bataller and D. Brenner, Liver fibrosis, Journal of Clinical Investigation, vol.115, issue.2, pp.209-218, 2005.
DOI : 10.1172/JCI24282DS1

H. Wu, S. Ghosh, X. Perrard, L. Feng, G. Garcia et al., T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity, Circulation, vol.115, issue.8, pp.1029-1038, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.638379

E. Rosen and B. Spiegelman, Adipocytes as regulators of energy balance and glucose homeostasis, Nature, vol.112, issue.7121, pp.847-853, 2006.
DOI : 10.1038/nature05483

R. Cancello, J. Tordjman, C. Poitou, G. Guilhem, J. Bouillot et al., Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity, Diabetes, vol.55, issue.6, pp.1554-1561, 2006.
DOI : 10.2337/db06-0133

C. Lumeng, J. Bodzin, and A. Saltiel, Obesity induces a phenotypic switch in adipose tissue macrophage polarization, Journal of Clinical Investigation, vol.117, issue.1, pp.175-184, 2007.
DOI : 10.1172/JCI29881

S. Caspar-bauguil, B. Cousin, M. Andre, M. Nibbelink, A. Galinier et al., Weight-dependent changes of immune system in adipose tissue: Importance of leptin, Experimental Cell Research, vol.312, issue.12, pp.2195-2202, 2006.
DOI : 10.1016/j.yexcr.2006.03.023

A. Marti, M. A. Martinez, and J. , Obesity and immune function relationships, Obesity Reviews, vol.129, issue.2, pp.131-140, 2001.
DOI : 10.1007/s001250051058

H. Schnaper, T. Hayashida, S. Hubchak, and A. Poncelet, TGF-?? signal transduction and mesangial cell fibrogenesis, American Journal of Physiology - Renal Physiology, vol.284, issue.2, pp.243-252, 2003.
DOI : 10.1152/ajprenal.00300.2002

E. Morrisey, Wnt Signaling and Pulmonary Fibrosis, The American Journal of Pathology, vol.162, issue.5, pp.1393-1397, 2003.
DOI : 10.1016/S0002-9440(10)64271-X

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851190

R. Chevalier, Obstructive nephropathy: towards biomarker discovery and gene therapy, Nature Clinical Practice Nephrology, vol.17, issue.3, pp.157-168, 2006.
DOI : 10.1038/ncpneph0098

C. Weiler-normann, J. Herkel, and A. Lohse, Mouse Models of Liver Fibrosis, Zeitschrift f??r Gastroenterologie, vol.45, issue.1, pp.43-50, 2007.
DOI : 10.1055/s-2006-927387

T. Wynn, Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases, Journal of Clinical Investigation, vol.117, issue.3, pp.524-529, 2007.
DOI : 10.1172/JCI31487

A. Sbarbati, F. Osculati, D. Silvagni, D. Benati, M. Galie et al., Obesity and Inflammation: Evidence for an Elementary Lesion, PEDIATRICS, vol.117, issue.1, pp.220-223, 2006.
DOI : 10.1542/peds.2004-2854

S. Ricard-blum, S. Bresson-hadni, D. Vuitton, G. Ville, and J. Grimaud, Hydroxypyridinium collagen cross-links in human liver fibrosis: Study of alveolar echinococcosis, Hepatology, vol.3, issue.4, pp.599-602, 1992.
DOI : 10.1002/hep.1840150408

URL : https://hal.archives-ouvertes.fr/hal-00313967

S. Friedman and M. Bansal, Reversal of hepatic fibrosis -fact or fantasy? Hepatology, pp.82-88, 2006.

T. Wynn, Fibrotic disease and the TH1/TH2 paradigm, Nature Reviews Immunology, vol.162, issue.8, pp.583-594, 2004.
DOI : 10.1038/383787a0

J. Iredale, Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ, Journal of Clinical Investigation, vol.117, issue.3, pp.539-548, 2007.
DOI : 10.1172/JCI30542

D. Mutch and K. Clement, Unraveling the Genetics of Human Obesity, PLoS Genetics, vol.74, issue.12, p.188, 2006.
DOI : 0002-9297(2004)074[0572:MRGVII]2.0.CO;2

A. Katz, S. Nambi, K. Mather, A. Baron, D. Follmann et al., Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans, The Journal of Clinical Endocrinology & Metabolism, vol.85, issue.7, pp.2402-2410, 2000.
DOI : 10.1210/jcem.85.7.6661

K. Clement, N. Viguerie, M. Diehn, A. Alizadeh, P. Barbe et al., In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone, Genome Research, vol.12, issue.2
DOI : 10.1101/gr.207702

H. Ruan, M. Zarnowski, S. Cushman, and H. Lodish, Standard Isolation of Primary Adipose Cells from Mouse Epididymal Fat Pads Induces Inflammatory Mediators and Down-regulates Adipocyte Genes, Journal of Biological Chemistry, vol.278, issue.48, pp.47585-47593, 2003.
DOI : 10.1074/jbc.M305257200

G. Smyth and T. Speed, Normalization of cDNA microarray data, Methods, vol.31, issue.4, pp.265-273, 2003.
DOI : 10.1016/S1046-2023(03)00155-5

J. Storey and R. Tibshirani, Statistical significance for genomewide studies, Proceedings of the National Academy of Sciences, vol.100, issue.16, pp.9440-9445, 2003.
DOI : 10.1073/pnas.1530509100

M. Kanehisa and S. Goto, KEGG: Kyoto Encyclopedia of Genes and Genomes, Nucleic Acids Research, vol.28, issue.1, pp.27-30, 2000.
DOI : 10.1093/nar/28.1.27

M. Ashburner, C. Ball, J. Blake, D. Botstein, H. Butler et al., Gene Ontology: tool for the unification of biology, Nature Genetics, vol.9, issue.1, pp.25-29, 2000.
DOI : 10.1038/75556

D. Maglott, J. Ostell, K. Pruitt, and T. Tatusova, Entrez Gene: gene-centered information at NCBI, Nucleic Acids Research, vol.35, issue.Database, pp.26-31, 2007.
DOI : 10.1093/nar/gkl993

URL : http://doi.org/10.1093/nar/gkq1237

C. Henegar, R. Cancello, S. Rome, H. Vidal, K. Clement et al., CLUSTERING BIOLOGICAL ANNOTATIONS AND GENE EXPRESSION DATA TO IDENTIFY PUTATIVELY CO-REGULATED BIOLOGICAL PROCESSES, Journal of Bioinformatics and Computational Biology, vol.04, issue.04, pp.833-852, 2006.
DOI : 10.1142/S0219720006002181

URL : https://hal.archives-ouvertes.fr/inserm-00147232

C. Henegar, K. Clement, J. Zucker, J. Fürnkranz, T. Scheffer et al., Unsupervised multipleinstance learning for functional profiling of genomic data, Lecture Notes in Computer Science: European Conference on Machine Learning, pp.186-197

A. Ng, M. Jordan, and Y. Weiss, On spectral clustering: analysis and an algorithm, Advances in Neural Information Processing Systems Edited by: Dietterich TG, pp.849-856

N. Bolshakova and F. Azuaje, Estimating the number of clusters in DNA microarray data, Methods Inf Med, vol.45, pp.153-157, 2006.

P. Shannon, A. Markiel, O. Ozier, N. Baliga, J. Wang et al., Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks, Genome Research, vol.13, issue.11
DOI : 10.1101/gr.1239303

B. Zhang and S. Horvath, A General Framework for Weighted Gene Co-Expression Network Analysis, Statistical Applications in Genetics and Molecular Biology, vol.4, issue.1, 2005.
DOI : 10.2202/1544-6115.1128

M. Hahn and A. Kern, Comparative genomics of centrality and