LIPID LEVELS AND CARDIOVASCULAR RISK IN ELDERLY WOMEN: A GENERAL POPULATION STUDY OF THE EFFECTS OF HORMONAL TREATMENT AND LIPID-LOWERING AGENTS

Abstract : Objective: To evaluate plasmatic lipid levels in elderly women in the general population as a function of use of lipid lowering agents (LLA) and hormone therapy (HT) Methods: 4271 women over 65 were recruited from three French cities. Analyses were performed after stratification by LLA treatment and HT and adjusting for a large range of socio-demographic and clinical factors. Results: Fifteen percent of women currently used HT (78% transdermal estradiol), and 30% were taking LLA. In this population, 4.6% of women were taking both HT and LLA (fibrate for 2.4% and statin for 2.2%). In non-LLA treated women, current HT was associated with lower total cholesterol, LDL-C, and non-HDL-C compared to never users. Women treated with LLA, also had lower total cholesterol, LDL-C, and non-HDL-C compared to non-LLA users, whereas triglyceride levels were the highest in statin users and lowest in fibrate users. Fibrate was associated with a more favorable lipid pattern than statin independently of HT use. In women without coronary heart disease or diabetes HT, statin, or fibrate were associated with lower LDL-C level risk based on NCEP guidelines (adjusted OR=0.67 [IC95=0.53;0.85], 0.38 [0.29;0.47], and 0.32 [0.25;0.42], respectively) with a possible interaction between fibrate and HT (0.18 [0.10;0.30]). Conclusions: Estradiol-based HT may lower atherogenic lipoproteins in post-menopausal women. In primary prevention of coronary heart disease, combining HT and fibrate may provide additional benefits compared to fibrate use.
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00243077
Contributeur : Dominique Villebrun <>
Soumis le : mercredi 18 février 2009 - 16:33:31
Dernière modification le : lundi 22 janvier 2018 - 10:30:16
Document(s) archivé(s) le : vendredi 7 mai 2010 - 22:16:11

Identifiants

  • HAL Id : inserm-00243077, version 1
  • PUBMED : 18202967

Collections

Citation

Anne-Marie Dupuy, Isabelle Carrière, Jacqueline Scali, Jean-Paul Cristol, Karen Ritchie, et al.. LIPID LEVELS AND CARDIOVASCULAR RISK IN ELDERLY WOMEN: A GENERAL POPULATION STUDY OF THE EFFECTS OF HORMONAL TREATMENT AND LIPID-LOWERING AGENTS. Climacteric, Taylor & Francis, 2008, 11 (1), pp.74-83. 〈inserm-00243077〉

Partager

Métriques

Consultations de la notice

203

Téléchargements de fichiers

181