Hepatitis C Virus Infection, New England Journal of Medicine, vol.345, issue.1, pp.41-52, 2001. ,
DOI : 10.1056/NEJM200107053450107
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection, New England Journal of Medicine, vol.347, issue.13, pp.975-82, 2002. ,
DOI : 10.1056/NEJMoa020047
Genetic diversity and evolution of hepatitis C virus - 15 years on, Journal of General Virology, vol.85, issue.11, pp.3173-88, 2004. ,
DOI : 10.1099/vir.0.80401-0
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties, Curr Top Microbiol Immunol, vol.242, pp.55-84, 2000. ,
DOI : 10.1007/978-3-642-59605-6_4
Tissue culture and animal models for hepatitis C virus, Clinics in Liver Disease, vol.7, issue.1, pp.23-43, 2003. ,
DOI : 10.1016/S1089-3261(02)00071-5
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line, Science, vol.285, issue.5424, pp.110-113, 1999. ,
DOI : 10.1126/science.285.5424.110
Efficient Initiation of HCV RNA Replication in Cell Culture, Science, vol.290, issue.5498, pp.1972-1974, 2000. ,
DOI : 10.1126/science.290.5498.1972
Innovation: Hepatitis C virus replicons: potential role for drug development, Nature Reviews Drug Discovery, vol.1, issue.11, pp.911-916, 2002. ,
DOI : 10.1038/nrd942
The hepatitis C virus replicon system: From basic research to clinical application, Journal of Hepatology, vol.43, issue.2, pp.210-216, 2005. ,
DOI : 10.1016/j.jhep.2005.05.013
Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons, Journal of Virology, vol.77, issue.9, pp.5487-5492, 2003. ,
DOI : 10.1128/JVI.77.9.5487-5492.2003
Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1???E2 Envelope Protein Complexes, The Journal of Experimental Medicine, vol.72, issue.5, pp.633-642, 2003. ,
DOI : 10.1093/emboj/21.12.2893
URL : https://hal.archives-ouvertes.fr/inserm-00133783
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles, Proceedings of the National Academy of Sciences, vol.100, issue.12, pp.7271-7276, 2003. ,
DOI : 10.1073/pnas.0832180100
Cell entry of hepatitis C virus, Virology, vol.348, issue.1, pp.1-12, 2006. ,
DOI : 10.1016/j.virol.2005.12.027
URL : https://hal.archives-ouvertes.fr/hal-00105453
Hepatitis C Virus-Like Particle Morphogenesis, Journal of Virology, vol.76, issue.8, pp.4073-4079, 2002. ,
DOI : 10.1128/JVI.76.8.4073-4079.2002
Hepatitis C virus ultrastructure and morphogenesis, Biology of the Cell, vol.96, issue.2, pp.103-108, 2004. ,
DOI : 10.1016/j.biolcel.2003.11.006
Hepatitis C Virus-Like Particle Budding: Role of the Core Protein and Importance of Its Asp111, Journal of Virology, vol.77, issue.18, pp.10131-10138, 2003. ,
DOI : 10.1128/JVI.77.18.10131-10138.2003
Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane, Cellular Microbiology, vol.72, issue.6, pp.1014-1027, 2007. ,
DOI : 10.1073/pnas.0503596102
URL : https://hal.archives-ouvertes.fr/inserm-00137282
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome, Nature Medicine, vol.37, issue.7, pp.791-796, 2005. ,
DOI : 10.1002/jmv.10297
Robust hepatitis C virus infection in vitro, Proceedings of the National Academy of Sciences, vol.102, issue.26, pp.9294-9299, 2005. ,
DOI : 10.1073/pnas.0503596102
Complete Replication of Hepatitis C Virus in Cell Culture, Science, vol.309, issue.5734, pp.623-626, 2005. ,
DOI : 10.1126/science.1114016
Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon, Gastroenterology, vol.125, issue.6, pp.1808-1817, 2003. ,
DOI : 10.1053/j.gastro.2003.09.023
Subcellular Localization of Hepatitis C Virus Structural Proteins in a Cell Culture System That Efficiently Replicates the Virus, Journal of Virology, vol.80, issue.6, pp.2832-2841, 2006. ,
DOI : 10.1128/JVI.80.6.2832-2841.2006
URL : https://hal.archives-ouvertes.fr/hal-00105500
In vitro veritas? The challenges of studying hepatitis C virus infectivity in a test tube, Journal of Hepatology, vol.46, issue.3, pp.355-358, 2007. ,
DOI : 10.1016/j.jhep.2006.12.004
A critical role for the chimpanzee model in the study of hepatitis C, Hepatology, vol.173, issue.6, pp.1469-1475, 2004. ,
DOI : 10.1002/hep.20268
Bad time for Bonzo? Experimental models of hepatitis C virus infection, replication, and pathogenesis, Hepatology, vol.33, issue.3, pp.489-495, 2001. ,
DOI : 10.1053/jhep.2001.23041
Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA, Proceedings of the National Academy of Sciences, vol.100, issue.17, pp.9962-9967, 2003. ,
DOI : 10.1073/pnas.1731505100
Hepatitis C virus replication in mice with chimeric human livers, Nature Medicine, vol.7, issue.8, pp.927-933, 2001. ,
DOI : 10.1038/90968
The Hepatitis C Virus (HCV)???Trimera Mouse: A Model for Evaluation of Agents against HCV, The Journal of Infectious Diseases, vol.185, issue.2, pp.153-161, 2002. ,
DOI : 10.1086/338266
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers, Nature Biotechnology, vol.21, issue.5, pp.519-544, 2003. ,
DOI : 10.1038/nbt817
A Novel Immunocompetent Rat Model of HCV Infection and Hepatitis, Gastroenterology, vol.128, issue.5, pp.1416-1423, 2005. ,
DOI : 10.1053/j.gastro.2005.03.015
uPA mice parallel outcomes in human clinical application, Hepatology, vol.43, pp.1346-1353, 2006. ,
Transgenic expression of hepatitis C virus structural proteins in the mouse, Hepatology, vol.25, issue.4, pp.1014-1021, 1997. ,
DOI : 10.1002/hep.510250437
Hepatitis C virus core and E2 protein expression in transgenic mice, Hepatology, vol.25, issue.3, pp.719-727, 1997. ,
DOI : 10.1002/hep.510250338
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice., Journal of General Virology, vol.78, issue.7, pp.1527-1531, 1997. ,
DOI : 10.1099/0022-1317-78-7-1527
The core protein of hepatitis C virus induces hepatocellular carcinoma
in transgenic mice, Nature Medicine, vol.50, issue.9, pp.1065-1067, 1998. ,
DOI : 10.1073/pnas.94.1.233
Lipid droplets: Proteins floating on a pool of fat, Current Biology, vol.11, issue.11, pp.446-449, 2001. ,
DOI : 10.1016/S0960-9822(01)00257-3
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells, Seminars in Cell & Developmental Biology, vol.10, issue.1, pp.51-58, 1999. ,
DOI : 10.1006/scdb.1998.0275
Lipid droplets: a unified view of a dynamic organelle, Nature Reviews Molecular Cell Biology, vol.13, issue.5, pp.373-378, 2006. ,
DOI : 10.1038/nrm1912
The Surface of Lipid Droplets Is a Phospholipid Monolayer with a Unique Fatty Acid Composition, Journal of Biological Chemistry, vol.277, issue.46, pp.44507-44512, 2002. ,
DOI : 10.1074/jbc.M207712200
Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis, Journal of Cell Science, vol.119, issue.20, pp.4215-4224, 2006. ,
DOI : 10.1242/jcs.03191
Characterization of Cell Lines Allowing Tightly Regulated Expression of Hepatitis C Virus Core Protein, Virology, vol.222, issue.1, pp.51-63, 1996. ,
DOI : 10.1006/viro.1996.0397
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets, Proceedings of the National Academy of Sciences, vol.94, issue.4, pp.1200-1205, 1997. ,
DOI : 10.1073/pnas.94.4.1200
Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein, Journal of General Virology, vol.81, issue.8, pp.1913-1925, 2000. ,
DOI : 10.1099/0022-1317-81-8-1913
The native form and maturation process of hepatitis C virus core protein, J Virol, vol.72, pp.6048-6055, 1998. ,
Targeting of Hepatitis C Virus Core Protein to Mitochondria through a Novel C-Terminal Localization Motif, Journal of Virology, vol.78, issue.15, pp.7958-7968, 2004. ,
DOI : 10.1128/JVI.78.15.7958-7968.2004
Detection of hepatitis C virus antigen by immuno-histochemical staining: a histological marker of hepatitis C virus infection, Journal of Hepatology, vol.20, issue.2, pp.275-81, 1994. ,
DOI : 10.1016/S0168-8278(05)80069-8
Optimization for the detection of hepatitis C virus antigens in the liver, Journal of Hepatology, vol.20, issue.1, pp.143-147, 1994. ,
DOI : 10.1016/S0168-8278(05)80481-7
Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets, The EMBO Journal, vol.21, issue.15, pp.3980-3988, 2002. ,
DOI : 10.1093/emboj/cdf414
Hepatitis C Virus Core Protein Is a Dimeric Alpha-Helical Protein Exhibiting Membrane Protein Features, Journal of Virology, vol.79, issue.17, pp.11353-11365, 2005. ,
DOI : 10.1128/JVI.79.17.11353-11365.2005
URL : https://hal.archives-ouvertes.fr/hal-00313681
The Domains Required to Direct Core Proteins of Hepatitis C Virus and GB Virus-B to Lipid Droplets Share Common Features with Plant Oleosin Proteins, Journal of Biological Chemistry, vol.277, issue.6, pp.4261-4270, 2002. ,
DOI : 10.1074/jbc.M108798200
Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly, Journal of General Virology, vol.87, issue.4, pp.855-860, 2006. ,
DOI : 10.1099/vir.0.81664-0
URL : https://hal.archives-ouvertes.fr/inserm-00128751
The lipid droplet is an important organelle for hepatitis C virus production, Nature Cell Biology, vol.71, issue.9, pp.1089-1097, 2007. ,
DOI : 10.1007/s00418-005-0061-5
Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus, Journal of General Virology, vol.88, issue.8, pp.2204-2213, 2007. ,
DOI : 10.1099/vir.0.82898-0
Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes, Journal of Viral Hepatitis, vol.47, issue.1, pp.2-14, 2000. ,
DOI : 10.1016/S0167-7799(98)01203-7
Hepatitis C virus biology, Cell Death and Differentiation, vol.10, issue.S1, pp.27-38, 2003. ,
DOI : 10.1038/sj.cdd.4401121
Interaction of hepatitis C virus core protein with retinoid X receptor ?? modulates its transcriptional activity, Hepatology, vol.274, issue.4, pp.937-946, 2002. ,
DOI : 10.1053/jhep.2002.32470
Hepatitis C Virus Core Protein Modulates Fatty Acid Metabolism and Thereby Causes Lipid Accumulation in the Liver, Digestive Diseases and Sciences, vol.39, issue.7, pp.1361-1371, 2005. ,
DOI : 10.1007/s10620-005-2788-1
Impaired expression of the peroxisome proliferator???activated receptor alpha during hepatitis C virus infection, Gastroenterology, vol.128, issue.2, pp.334-342, 2005. ,
DOI : 10.1053/j.gastro.2004.11.016
URL : https://hal.archives-ouvertes.fr/hal-00187509
Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection, Alimentary Pharmacology and Therapeutics, vol.284, issue.1, pp.107-114, 2006. ,
DOI : 10.1074/jbc.M006577200
Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis, The FASEB Journal, vol.16, issue.2, pp.185-194, 2002. ,
DOI : 10.1096/fj.01-0396com
Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein, Gastroenterology, vol.122, issue.2, pp.366-375, 2002. ,
DOI : 10.1053/gast.2002.30983
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus, Gastroenterology, vol.122, issue.2, pp.352-365, 2002. ,
DOI : 10.1053/gast.2002.31001
Critical role of PA28?? in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis, Proceedings of the National Academy of Sciences, vol.104, issue.5, pp.1661-1666, 2007. ,
DOI : 10.1073/pnas.0607312104
Interaction between the Hepatitis C Virus and the Immune System, Seminars in Liver Disease, vol.20, issue.02, pp.127-141, 2000. ,
DOI : 10.1055/s-2000-9946
Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients, Journal of Hepatology, vol.37, issue.6, pp.837-842, 2002. ,
DOI : 10.1016/S0168-8278(02)00299-4
Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies, Gut, vol.52, issue.2, pp.288-292, 2003. ,
DOI : 10.1136/gut.52.2.288
The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients, Journal of Hepatology, vol.40, issue.3, pp.484-90, 2004. ,
DOI : 10.1016/j.jhep.2003.11.004
Impact of steatosis on progression of fibrosis in patients with mild hepatitis C, Hepatology, vol.34, issue.Suppl 1, pp.82-87, 2005. ,
DOI : 10.1002/hep.20519
Steatosis: Co-factor in other liver diseases, Hepatology, vol.42, issue.1, pp.5-13, 2005. ,
DOI : 10.1002/hep.20750
Hepatic steatosis in chronic hepatitis B and C: Predictors, distribution and effect on fibrosis, Journal of Hepatology, vol.43, issue.1, pp.38-44, 2005. ,
DOI : 10.1016/j.jhep.2005.01.031
STEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER?, Gut, vol.55, issue.1, pp.123-130, 2006. ,
DOI : 10.1136/gut.2005.069757
Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity, Hepatology, vol.33, issue.6, pp.1358-1364, 2001. ,
DOI : 10.1053/jhep.2001.24432
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3, Journal of Hepatology, vol.33, issue.1, pp.106-115, 2000. ,
DOI : 10.1016/S0168-8278(00)80166-X
Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol, Hepatology, vol.157, issue.3, pp.729-765, 2002. ,
DOI : 10.1053/jhep.2002.35064
Steatosis affects chronic hepatitis C progression in a genotype specific way, Gut, vol.53, issue.3, pp.406-412, 2004. ,
DOI : 10.1136/gut.2003.018770
Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections, Journal of Viral Hepatitis, vol.122, issue.5, pp.455-458, 2004. ,
DOI : 10.1016/S0168-8278(00)00036-2
Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C, Journal of Viral Hepatitis, vol.89, issue.3, pp.199-205, 2006. ,
DOI : 10.1111/j.1572-0241.2002.05705.x
Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response, Hepatology, vol.94, issue.5, pp.1266-1272, 2002. ,
DOI : 10.1053/jhep.2002.36370
Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis, Gut, vol.53, issue.3, pp.420-424, 2004. ,
DOI : 10.1136/gut.2002.009936
Mechanisms and significance of liver steatosis in hepatitis C virus infection, World Journal of Gastroenterology, vol.12, issue.42, pp.6756-6765, 2006. ,
DOI : 10.3748/wjg.v12.i42.6756
Hepatitis C and steatosis: a reappraisal, Journal of Viral Hepatitis, vol.41, issue.1, pp.73-80, 2006. ,
DOI : 10.1136/gut.2003.027581
Relationship Between Steatosis, Inflammation, and Fibrosis in Chronic Hepatitis C: A Meta-Analysis of Individual Patient Data, Gastroenterology, vol.130, issue.6, pp.1636-1642, 2006. ,
DOI : 10.1053/j.gastro.2006.03.014
Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection, Cancer, vol.59, issue.12, pp.3036-3043, 2003. ,
DOI : 10.1002/cncr.11427
An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation, Journal of Hepatology, vol.42, issue.5, pp.744-751, 2005. ,
DOI : 10.1016/j.jhep.2004.12.034
The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model, Gut, vol.56, issue.9, pp.1302-1308, 2007. ,
DOI : 10.1136/gut.2006.108647
URL : https://hal.archives-ouvertes.fr/inserm-00167783
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: Genotype-3a core has a stronger effect than genotype-1b core, Journal of Hepatology, vol.46, issue.6, pp.985-987, 2007. ,
DOI : 10.1016/j.jhep.2006.10.019
Structural Determinants That Target the Hepatitis C Virus Core Protein to Lipid Droplets, Journal of Biological Chemistry, vol.281, issue.31, pp.22236-22247, 2006. ,
DOI : 10.1074/jbc.M601031200
URL : https://hal.archives-ouvertes.fr/hal-00313671
Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing Particles, Journal of Virology, vol.76, issue.14, pp.6919-6928, 2002. ,
DOI : 10.1128/JVI.76.14.6919-6928.2002
Association between Hepatitis C Virus and Very-Low-Density Lipoprotein (VLDL)/LDL Analyzed in Iodixanol Density Gradients, Journal of Virology, vol.80, issue.5, pp.2418-2428, 2006. ,
DOI : 10.1128/JVI.80.5.2418-2428.2006
Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins, Journal of General Virology, vol.87, issue.10, pp.2983-2991, 2006. ,
DOI : 10.1099/vir.0.82033-0
URL : https://hal.archives-ouvertes.fr/inserm-00139590