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Effect of rebamipide on the colonic barrier in interleukin 10 deficient mice

Abstract : Our aim was to study the effect of a mucosal protective agent, rebamipide, on the colonic barrier and the immune response in colitis-prone interleukin-10 deficient (IL-10-/-) C57BL/6 mice infected with Helicobacter hepaticus. After sacrifice, in all mice, control, or previously infected with H. hepaticus, or previously infected and treated with rebamipide enema, a histological examination of colonic samples was performed, intestinal permeability was studied in Ussing chamber, and mesenteric lymph node proliferation and cytokine secretion were measured. Mice treated with rebamipide, presented a reinforcement of the distal colonic epithelial barrier, an increase of mesenteric lymph node cells proliferation and of IFNΓ and IL-12 secretion. These results indicate that in IL-10-/- mice with mild colitis, rectally administered rebamipide reinforces the distal colonic barrier and has a slight Th1 immuno-stimulatory effect on mesenteric lymph node cells. These properties could be helpful in the management of some inflammatory bowel diseases.
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Contributor : Martine Heyman Connect in order to contact the contributor
Submitted on : Monday, January 21, 2008 - 3:50:55 PM
Last modification on : Tuesday, August 11, 2020 - 3:10:03 PM
Long-term archiving on: : Thursday, April 15, 2010 - 1:52:04 AM


  • HAL Id : inserm-00211574, version 1
  • PUBMED : 17186389



David Laharie, Sandrine Ménard, Corinne Asencio, Teresita Vidal-Martinez, Anne Rullier, et al.. Effect of rebamipide on the colonic barrier in interleukin 10 deficient mice. Digestive Diseases and Sciences, Springer Verlag, 2006, 52 (1), pp.84-92. ⟨inserm-00211574⟩



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