Skip to Main content Skip to Navigation
Journal articles

Familial history of cancer and childhood acute leukemia: a French population-based case-control study.

Abstract : A case-control study was conducted to investigate the role of a familial history of cancer in the etiology of childhood acute leukemia. The history of cancer in the relatives of 472 cases was compared with that of 567 population-based controls. Recruitment was frequency matched on age, sex and region. The familial history of cancer in each child's relatives was reported by the mother in response to a standardized self-administered questionnaire. A familial history of solid tumor in first or second-degree relatives was associated with an increased risk of acute lymphoblastic leukemia (odds ratio (OR)=1.6 [95% confidence interval, 1.2-2.1]), while a familial history of hematopoietic malignancies in first or second-degree relatives was associated with an increased risk of acute myeloid leukemia (OR=4.3 [1.4-13]). The ORs for the histories of cancer increased with the number of relatives with cancer (OR=1.5 [1.1-2.0] for one relative and OR=2.3 [1.3-3.8] for two relatives or more; Ptrend<0.0001). Significant associations between childhood acute leukemia and familial history of genital cancers and brain tumor were also observed (OR=2.7 [1.2-5.8] and OR=10.7 [1.3-86], respectively). This study supports the hypothesis that a familial history of cancer may play a role in the etiology of childhood acute leukemia. It also evidences some specific associations that require further investigation.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00207608
Contributor : U754 Secretariat <>
Submitted on : Tuesday, October 28, 2008 - 10:38:35 AM
Last modification on : Wednesday, September 16, 2020 - 4:51:30 PM
Long-term archiving on: : Tuesday, April 13, 2010 - 11:06:34 PM

Identifiers

Collections

Citation

Mahaut Ripert, Florence Menegaux, Yves Perel, Françoise Méchinaud, Emmanuel Plouvier, et al.. Familial history of cancer and childhood acute leukemia: a French population-based case-control study.. European Journal of Cancer Prevention, Lippincott, Williams & Wilkins, 2007, 16 (5), pp.466-70. ⟨10.1097/01.cej.0000243849.82232.cb⟩. ⟨inserm-00207608⟩

Share

Metrics

Record views

399

Files downloads

1118