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Familial history of cancer and childhood acute leukemia: a French population-based case-control study.

Mahaut Ripert 1 Florence Menegaux 1, * Yves Perel 2 Françoise Méchinaud 3 Emmanuel Plouvier 4 Virginie Gandemer 5 Patrick Lutz 6 Jean-Pierre Vannier 7 Jean-Pierre Lamagnére 8 Geneviève Margueritte 9 Patrick Boutard 10 Alain Robert 11 Corinne Armari-Alla 12 Martine Munzer 13 Frédéric Millot 14 Lionel de Lumley 15 Christian Berthou 16 Xavier Rialland 17 Brigitte Pautard 18 Jacqueline Clavel 1
* Corresponding author
1 Epidémiologie environnementale des cancers
2 Hôpital Pellegrin
3 Hôpital mère et enfant
4 Hôpital Saint-Jacques
5 Hôpital Sud
6 Hôpital Civil
7 CHU Rouen
8 CHRU Clocheville
9 SFO Enseignement
10 Hôpital Côte de Nacre [CHU Caen]
11 Hôpital d'enfants
12 Hôpital de la Tronche
13 American Memorial Hospital
14 Hôpital Jean Bernard
15 CHU Limoges
16 Hôpital Morvan
17 Centre Robert Debré
18 CHU Amiens-Picardie
Abstract : A case-control study was conducted to investigate the role of a familial history of cancer in the etiology of childhood acute leukemia. The history of cancer in the relatives of 472 cases was compared with that of 567 population-based controls. Recruitment was frequency matched on age, sex and region. The familial history of cancer in each child's relatives was reported by the mother in response to a standardized self-administered questionnaire. A familial history of solid tumor in first or second-degree relatives was associated with an increased risk of acute lymphoblastic leukemia (odds ratio (OR)=1.6 [95% confidence interval, 1.2-2.1]), while a familial history of hematopoietic malignancies in first or second-degree relatives was associated with an increased risk of acute myeloid leukemia (OR=4.3 [1.4-13]). The ORs for the histories of cancer increased with the number of relatives with cancer (OR=1.5 [1.1-2.0] for one relative and OR=2.3 [1.3-3.8] for two relatives or more; Ptrend<0.0001). Significant associations between childhood acute leukemia and familial history of genital cancers and brain tumor were also observed (OR=2.7 [1.2-5.8] and OR=10.7 [1.3-86], respectively). This study supports the hypothesis that a familial history of cancer may play a role in the etiology of childhood acute leukemia. It also evidences some specific associations that require further investigation.
Keywords : case-control study childhood leukemia familial history
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https://www.hal.inserm.fr/inserm-00207608
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Submitted on : Tuesday, October 28, 2008 - 10:38:35 AM
Last modification on : Wednesday, October 14, 2020 - 4:10:23 AM
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Mahaut Ripert, Florence Menegaux, Yves Perel, Françoise Méchinaud, Emmanuel Plouvier, et al.. Familial history of cancer and childhood acute leukemia: a French population-based case-control study.. European Journal of Cancer Prevention, Lippincott, Williams & Wilkins, 2007, 16 (5), pp.466-70. ⟨10.1097/01.cej.0000243849.82232.cb⟩. ⟨inserm-00207608⟩

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