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Journal articles
The solution structure of the invasive tip complex from Afa/Dr fibrils.
Ernesto Cota
1
Celine Jones
2
Peter Simpson
1
Harri Altroff
2
Kirstine L Anderson
1
Laurence Du Merle
3
Julie Guignot
4
Alain Servin
4, *
Chantal Le Bouguénec
3
Helen Mardon
2
Stephen Matthews
1
Kirstine L Anderson 1
Author
Laurence Du Merle 3
Author
Julie Guignot 4
Author
Alain L. Servin 4
Correspondent author
1
THE DIVISION OF MOLECULAR BIOSCIENCES (South Kensington London SW7 2 AZ - United Kingdom)
- Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
2
Nuffield Dept. Obstetrics and Gynaecology (Division of Medical Sciences University of Oxford Women's Centre Level 3, John Radcliffe Hospital Headington, OXFORD OX3 9 DU - United Kingdom)
- University of Oxford Women's Centre (France)
3
Pathogénie Bactérienne des Muqueuses (25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
4
Pathogenes et Fonctions des Cellules Epitheliales Polarisees (Faculte de Pharmacie PARIS XI 5, Rue Jean-Baptiste Clement 92296 CHATENAY MALABRY CEDEX - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U510 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.
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Journal articles
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https://www.hal.inserm.fr/inserm-00203948
Contributor : Patrice Codogno <>
Submitted on : Friday, January 11, 2008 - 2:45:10 PM
Last modification on : Wednesday, September 16, 2020 - 4:51:26 PM
Contributor : Patrice Codogno <>
Submitted on : Friday, January 11, 2008 - 2:45:10 PM
Last modification on : Wednesday, September 16, 2020 - 4:51:26 PM
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- HAL Id : inserm-00203948, version 1
- DOI : 10.1111/j.1365-2958.2006.05375.x
- PUBMED : 16965519
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Ernesto Cota, Celine Jones, Peter Simpson, Harri Altroff, Kirstine L Anderson, et al.. The solution structure of the invasive tip complex from Afa/Dr fibrils.. Molecular Microbiology, Wiley, 2006, 62 (2), pp.356-66. ⟨10.1111/j.1365-2958.2006.05375.x⟩. ⟨inserm-00203948⟩
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