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Positive association between congenital anomalies and risk of neuroblastoma.

Abstract : BACKGROUND: Case reports and epidemiological studies have suggested a relationship between congenital anomalies and childhood cancer, but some potential associations remain inconsistent. In this study, we investigated the association between congenital anomalies and neuroblastoma. PROCEDURE: We used data of a case-control study on neuroblastoma conducted from 1992 to 1994, including 538 children aged 0-19 years with newly diagnosed, histologically confirmed neuroblastoma and 504 controls identified by telephone random-digit dialing and matched to cases on date of birth. Information on congenital anomalies and potential confounding factors was collected through maternal telephone interviews using a structured questionnaire. We estimated odds ratios (OR) and 95% confidence intervals (CI), adjusted for reference age at diagnosis, mother's educational level, mother's race, and household income at birth. RESULTS: An association between the maternal report of any congenital anomalies and neuroblastoma (OR = 2.58; CI = 1.57-4.25) was observed. Neuroblastoma risk increased with increasing number of anomalies per child (OR = 3.90, CI = 1.27-11.9 for two anomalies or more), and when we restricted analyses to major anomalies (OR = 7.53, CI = 2.23-25.5). Genitourinary anomalies (OR = 5.84, CI = 1.67-20.4) and cardiac anomalies (OR = 4.27, CI = 1.22-15.0) had an elevated, but imprecise neuroblastoma risk. CONCLUSIONS: Our findings support the hypothesis of an association between neuroblastoma and congenital, especially urogenital and cardiac, anomalies.
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Submitted on : Tuesday, December 18, 2007 - 11:52:31 AM
Last modification on : Wednesday, August 21, 2019 - 10:22:06 AM

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Florence Menegaux, Andrew Olshan, Pamela Reitnauer, Julie Blatt, Susan Cohn. Positive association between congenital anomalies and risk of neuroblastoma.. Pediatric Blood and Cancer, Wiley, 2005, 45 (5), pp.649-55. ⟨10.1002/pbc.20263⟩. ⟨inserm-00199015⟩



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