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Interaction between hydroxypropyl methylcellulose and biphasic calcium phosphate after steam sterilisation: capillary gas chromatography studies.

Abstract : The purpose of this study was to check the chemical stability of an injectable bone substitute (IBS) composed of a 50/50 w/w mixture of 2.92% hydroxypropyl methylcellulose (HPMC) solution in deionized water containing biphasic calcium phosphate (BCP) granules (60% hydroxyapatite/40% beta-tricalcium phosphate w/w). After separation of the organic and mineral phases, capillary gas chromatography (GC) was used to study the possible modification of HPMC due to the contact with BCP granules following steam sterilisation and 32 days storage at room temperature. HPMC was extracted from IBS in aqueous medium, and a dialytic method was then used to extract calcium phosphate salts from the HPMC. The percentage of HPMC extracted from BCP was 98.5%+/-0.5%, as measured by UV. GC showed no chemical modifications after steam sterilisation and storage.
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https://www.hal.inserm.fr/inserm-00198801
Contributor : Pierre Weiss <>
Submitted on : Tuesday, December 18, 2007 - 10:37:02 AM
Last modification on : Thursday, April 5, 2018 - 10:36:33 AM
Long-term archiving on: : Monday, April 12, 2010 - 8:15:23 AM

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  • HAL Id : inserm-00198801, version 1
  • PUBMED : 11556737

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Xavier Bourges, Michel Schmitt, Yves Amouriq, Guy Daculsi, Gilbert Legeay, et al.. Interaction between hydroxypropyl methylcellulose and biphasic calcium phosphate after steam sterilisation: capillary gas chromatography studies.. Journal of Biomaterials Science, Polymer Edition, Taylor & Francis, 2001, 12 (6), pp.573-9. ⟨inserm-00198801⟩

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