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Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use.

Abstract : Synthesis of grafting silane on a hydro soluble cellulose ether (HPMC) was described. In alkaline medium, this derivate is under gel form. With a decrease of the pH, a self-hardening occurs due to the silanol condensation. For potential biomedical use, we described the silated-HPMC synthesis, the gel behavior after steam sterilization and the parameters of the silanol condensation i.e. pH, silane percentage and temperature. Minimum kinetic of the condensation was observed for pH between 5.5 and 6.5. So temperature catalyzed the reaction and the self-hardening speed was increased by silane percentage.
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https://www.hal.inserm.fr/inserm-00198799
Contributor : Pierre Weiss <>
Submitted on : Tuesday, December 18, 2007 - 10:43:00 AM
Last modification on : Friday, August 31, 2018 - 1:59:34 PM
Long-term archiving on: : Monday, April 12, 2010 - 8:15:16 AM

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  • HAL Id : inserm-00198799, version 1
  • PUBMED : 12509115

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Xavier Bourges, Pierre Weiss, Guy Daculsi, Gilbert Legeay. Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use.. Advances in Colloid and Interface Science, Elsevier, 2002, 99 (3), pp.215-28. ⟨inserm-00198799⟩

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