CIRB - Centre interdisciplinaire de recherche en biologie, INSERM - Institut National de la Santé et de la Recherche Médicale : U667, UPMC - Université Pierre et Marie Curie - Paris 6
Abstract : The basal ganglia (BG) provide a major integrative system of the forebrain involved in the organization of goal-directed behaviour. Pathological alteration of BG function leads to major motor and cognitive impairments such as observed in Parkinson's disease. Recent advances in BG research stress the role of neural oscillations and synchronization in the normal and pathological function of BG. As demonstrated in several brain structures, these patterns of neural activity can emerge from electrically coupled neuronal networks. This review aims at addressing the presence, functionality and putative role of electrical synapses in BG, with a particular emphasis on the striatum and the substantia nigra pars compacta (SNc), two main BG nuclei in which the existence and functional properties of neuronal coupling are best documented.
https://www.hal.inserm.fr/inserm-00187463
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Marie Vandecasteele, Jean-Michel Deniau, Jacques Glowinski, Laurent Venance. Electrical synapses in basal ganglia.. Reviews in the Neurosciences, Walter de Gruyter, 2007, 18 (1), pp.15-35. ⟨10.1515/revneuro.2007.18.1.15⟩. ⟨inserm-00187463⟩