P. Bitterman, Pathogenesis of fibrosis in acute lung injury, The American Journal of Medicine, vol.92, issue.6, pp.39-43, 1992.
DOI : 10.1016/0002-9343(92)90606-C

R. Qiao, B. Zhou, J. Liebler, X. Li, E. Crandall et al., Identification of Three Genes of Known Function Expressed by Alveolar Epithelial Type I Cells, American Journal of Respiratory Cell and Molecular Biology, vol.29, issue.1, pp.98-105, 2003.
DOI : 10.1165/rcmb.2002-0196OC

J. Kopp, G. Wang, P. Kulmburg, S. Schultze-mosgau, J. Huan et al., Accelerated Wound Healing by In vivo Application of Keratinocytes Overexpressing KGF, Molecular Therapy, vol.10, issue.1, pp.86-96, 2004.
DOI : 10.1016/j.ymthe.2004.04.016

P. Finch, J. Rubin, T. Miki, R. D. Aaronson, and S. , Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth, Science, vol.245, issue.4919, pp.752-755, 1989.
DOI : 10.1126/science.2475908

L. Ware and M. Matthay, Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.282, issue.5, pp.924-940, 2002.
DOI : 10.1152/ajplung.00439.2001

A. Grazul-bilska, M. Johnson, J. Bilski, D. Redmer, L. Reynolds et al., Wound healing: The role of growth factors, Drugs of Today, vol.39, issue.10, pp.787-800, 2003.
DOI : 10.1358/dot.2003.39.10.799472

R. Deterding, A. Havill, T. Yano, S. Middleton, C. Jacoby et al., Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor, Proc Assoc Am Physicians, vol.109, pp.254-268, 1997.

E. Yi, S. Williams, H. Lee, D. Malicki, E. Chin et al., Keratinocyte growth factor ameliorates radiation-and bleomycininduced lung injury and mortality, Am J Pathol, vol.149, pp.1963-1970, 1996.

R. Panos, J. Rubin, K. Csaky, S. Aaronson, and R. Mason, Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium., Journal of Clinical Investigation, vol.92, issue.2, pp.969-977, 1993.
DOI : 10.1172/JCI116673

T. Ulich, E. Yi, K. Longmuir, S. Yin, R. Biltz et al., Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo., Journal of Clinical Investigation, vol.93, issue.3, pp.1298-1306, 1994.
DOI : 10.1172/JCI117086

P. Ray, Y. Devaux, D. Stolz, M. Yarlagadda, S. Watkins et al., Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia, Proceedings of the National Academy of Sciences, vol.100, issue.10, pp.6098-6103, 2003.
DOI : 10.1073/pnas.1031851100

R. Panos, P. Bak, W. Simonet, J. Rubin, and L. Smith, Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats., Journal of Clinical Investigation, vol.96, issue.4, pp.2026-2033, 1995.
DOI : 10.1172/JCI118250

T. Yano, R. Deterding, W. Simonet, J. Shannon, and R. Mason, Keratinocyte growth factor reduces lung damage due to acid instillation in rats., American Journal of Respiratory Cell and Molecular Biology, vol.15, issue.4, pp.433-442, 1996.
DOI : 10.1165/ajrcmb.15.4.8879176

S. Werner, Keratinocyte Growth Factor: A Unique Player in Epithelial Repair Processes, Cytokine & Growth Factor Reviews, vol.9, issue.2, pp.153-165, 1998.
DOI : 10.1016/S1359-6101(98)00010-0

C. Barazzone, Y. Donati, A. Rochat, C. Vesin, C. Kan et al., Keratinocyte Growth Factor Protects Alveolar Epithelium and Endothelium from Oxygen-Induced Injury in Mice, The American Journal of Pathology, vol.154, issue.5, pp.1479-1487, 1999.
DOI : 10.1016/S0002-9440(10)65402-8

K. Atabai, M. Ishigaki, T. Geiser, I. Ueki, M. Matthay et al., Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.283, issue.1, pp.163-169, 2002.
DOI : 10.1152/ajplung.00396.2001

S. Galiacy, E. Planus, H. Lepetit, S. Fereol, V. Laurent et al., Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro, Experimental Cell Research, vol.283, issue.2, pp.215-229, 2003.
DOI : 10.1016/S0014-4827(02)00049-6

URL : https://hal.archives-ouvertes.fr/inserm-00186840

S. Zigmond, Cell locomotion and chemotaxis, Current Opinion in Cell Biology, vol.1, issue.1, pp.80-86, 1989.
DOI : 10.1016/S0955-0674(89)80041-9

J. Romer, T. Bugge, C. Pyke, L. Lund, M. Flick et al., Impaired wound healing in mice with a disrupted plasminogen gene, Nature Medicine, vol.10, issue.3, pp.287-292, 1996.
DOI : 10.1038/368419a0

M. Lazar, P. Christensen, M. Du, B. Yu, N. Subbotina et al., Plasminogen Activator Inhibitor???1 Impairs Alveolar Epithelial Repair by Binding to Vitronectin, American Journal of Respiratory Cell and Molecular Biology, vol.31, issue.6, pp.672-678, 2004.
DOI : 10.1165/rcmb.2004-0025OC

S. Stefansson and D. Lawrence, Old Dogs and New Tricks, Proteases, Inhibitors, and Cell Migration, Science Signaling, vol.2003, issue.189, p.24, 2003.
DOI : 10.1126/stke.2003.189.pe24

R. Czekay and D. Loskutoff, Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment, Exp Biol Med, vol.229, pp.1090-1096, 2004.

L. Kjoller, S. Kanse, T. Kirkegaard, K. Rodenburg, E. Ronne et al., Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation, Experimental Cell Research, vol.232, issue.2, pp.420-429, 1997.
DOI : 10.1006/excr.1997.3540

B. Chazaud, S. Bonavaud, A. Plonquet, M. Pouchelet, R. Gherardi et al., Involvement of the [uPAR:uPA:PAI-1:LRP] Complex in Human Myogenic Cell Motility, Experimental Cell Research, vol.258, issue.2, pp.237-244, 2000.
DOI : 10.1006/excr.2000.4934

S. Bonavaud, C. Charriere-bertrand, C. Rey, M. Leibovitch, N. Pedersen et al., Evidence of a non-conventional role for the urokinase tripartite complex (uPAR/uPA/PAI-1) in myogenic cell fusion, J Cell Sci, vol.110, pp.1083-1089, 1997.

D. Waltz, L. Natkin, R. Fujita, Y. Wei, and H. Chapman, Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin., Journal of Clinical Investigation, vol.100, issue.1, pp.58-67, 1997.
DOI : 10.1172/JCI119521

E. Planus, G. Barlovatz-meimon, R. Rogers, S. Bonavaud, D. Ingber et al., Binding of urokinase to plasminogen activator inhibitor type-1 mediates cell adhesion and spreading, J Cell Sci, vol.110, pp.1091-1098, 1997.

B. Chazaud, R. Ricoux, C. Christov, A. Plonquet, R. Gherardi et al., Promigratory Effect of Plasminogen Activator Inhibitor-1 on Invasive Breast Cancer Cell Populations, The American Journal of Pathology, vol.160, issue.1, pp.237-246, 2002.
DOI : 10.1016/S0002-9440(10)64367-2

W. Xia, C. De-bock, G. Murrell, and Y. Wang, Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing, Journal of Orthopaedic Research, vol.21, issue.5, pp.819-825, 2003.
DOI : 10.1016/S0736-0266(03)00058-5

S. Pawar, S. Kartha, and F. Toback, Differential gene expression in migrating renal epithelial cells after wounding, Journal of Cellular Physiology, vol.18, issue.3, pp.556-565, 1995.
DOI : 10.1002/jcp.1041650314

K. Providence, S. Kutz, L. Staiano-coico, and P. Higgins, PAI-1 gene expression is regionally induced in wounded epithelial cell monolayers and required for injury repair, Journal of Cellular Physiology, vol.37, issue.2, pp.269-280, 2000.
DOI : 10.1002/(SICI)1097-4652(200002)182:2<269::AID-JCP16>3.0.CO;2-E

K. Providence, L. White, J. Tang, J. Gonclaves, L. Staiano-coico et al., Epithelial monolayer wounding stimulates binding of PAI-1, a New Matricellular Protein, 1631.

K. Providence and P. Higgins, PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair, Journal of Cellular Physiology, vol.19, issue.2, pp.297-308, 2004.
DOI : 10.1002/jcp.20016

C. Legrand, M. Polette, J. Tournier, S. De-bentzmann, E. Huet et al., uPA/Plasmin System-Mediated MMP-9 Activation Is Implicated in Bronchial Epithelial Cell Migration, Experimental Cell Research, vol.264, issue.2, pp.326-336, 2001.
DOI : 10.1006/excr.2000.5125

URL : https://hal.archives-ouvertes.fr/inserm-00153411

F. Li, J. Goncalves, K. Faughnan, M. Steiner, I. Pagan-charry et al., Targeted Inhibition of Wound-Induced PAI-1 Expression Alters Migration and Differentiation in Human Epidermal Keratinocytes, Experimental Cell Research, vol.258, issue.2, pp.245-253, 2000.
DOI : 10.1006/excr.2000.4918

J. Chan, D. Duszczyszyn, F. Castellino, and V. Ploplis, Accelerated Skin Wound Healing in Plasminogen Activator Inhibitor-1-Deficient Mice, The American Journal of Pathology, vol.159, issue.5, pp.1681-1688, 2001.
DOI : 10.1016/S0002-9440(10)63015-5

E. Sage and P. Bornstein, Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin, J Biol Chem, vol.266, pp.14831-14834, 1991.

C. Clerici, G. Friedlander, and C. Amiel, Impairment of sodium-coupled uptakes by hydrogen peroxide in alveolar type II cells: protective effect of d-alpha-tocopherol, Am J Physiol, vol.262, pp.542-548, 1992.

C. Garat, F. Kheradmand, K. Albertine, H. Folkesson, and M. Matthay, Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro, Am J Physiol, vol.271, pp.844-853, 1996.

Z. Wang, G. Sosne, and M. Kurpakus-wheater, Plasminogen activator inhibitor-1 (PAI-1) stimulates human corneal epithelial cell adhesion and migration in vitro, Experimental Eye Research, vol.80, issue.1, pp.1-8, 2005.
DOI : 10.1016/j.exer.2004.06.006

G. Hjortland, K. Bjornland, S. Pettersen, S. Garman-vik, E. Emilsen et al., Modulation of glioma cell invasion and motility by adenoviral gene transfer of PAI-1, Clinical & Experimental Metastasis, vol.20, issue.4, pp.301-309, 2003.
DOI : 10.1023/A:1024040718238

B. Whitley, D. Palmieri, C. Twerdi, and F. Church, Expression of active plasminogen activator inhibitor-1 reduces cell migration and invasion in breast and gynecological cancer cells, Experimental Cell Research, vol.296, issue.2, pp.151-162, 2004.
DOI : 10.1016/j.yexcr.2004.02.022

R. Mason, M. Lewis, K. Edeen, K. Mccormick-shannon, L. Nielsen et al., Maintenance of surfactant protein A and D secretion by rat alveolar type II cells in vitro, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.282, issue.2, pp.249-258, 2002.
DOI : 10.1152/ajplung.00027.2001

J. Stern, S. Jaffre, M. Dehoux, and B. Crestani, Keratinocyte growth factor and hepatocyte growth factor: their roles in alveolar epithelial repair, Rev Mal Respir, vol.20, pp.896-903, 2003.

P. Finch and J. Rubin, Keratinocyte Growth Factor???Fibroblast Growth Factor 7, a Homeostatic Factor with Therapeutic Potential for Epithelial Protection and Repair, Adv Cancer Res, vol.91, pp.69-136, 2004.
DOI : 10.1016/S0065-230X(04)91003-2

R. Tsuboi, C. Sato, Y. Kurita, R. D. Rubin, J. Ogawa et al., Keratinocyte Growth Factor (FGF-7) Stimulates Migration and Plasminogen Activator Activity of Normal Human Keratinocytes, Journal of Investigative Dermatology, vol.101, issue.1, pp.49-53, 1993.
DOI : 10.1111/1523-1747.ep12358892

G. Wagenaar, S. Horst, M. Van-gastelen, L. Leijser, T. Mauad et al., Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress, Free Radical Biology and Medicine, vol.36, issue.6, pp.782-801, 2004.
DOI : 10.1016/j.freeradbiomed.2003.12.007

H. Lijnen, Pleiotropic functions of plasminogen activator inhibitor-1, Journal of Thrombosis and Haemostasis, vol.268, issue.1, pp.35-45, 2005.
DOI : 10.1172/JCI200318038

G. Deng, S. Curriden, S. Wang, S. Rosenberg, and D. Loskutoff, Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?, The Journal of Cell Biology, vol.134, issue.6, pp.1563-1571, 1996.
DOI : 10.1083/jcb.134.6.1563

D. Lawrence, S. Palaniappan, S. Stefansson, S. Olson, A. Francis-chmura et al., Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin: IMPLICATIONS FOR THE REGULATION OF PERICELLULAR PROTEOLYSIS, Journal of Biological Chemistry, vol.272, issue.12, pp.7676-7680, 1997.
DOI : 10.1074/jbc.272.12.7676

D. Seiffert, J. Mimuro, R. Schleef, and D. Loskutoff, Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin, Cell Differentiation and Development, vol.32, issue.3, pp.287-292, 1990.
DOI : 10.1016/0922-3371(90)90041-T

B. Degryse, J. Neels, R. Czekay, K. Aertgeerts, Y. Kamikubo et al., The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1, Journal of Biological Chemistry, vol.279, issue.21, pp.22595-22604, 2004.
DOI : 10.1074/jbc.M313004200

R. Czekay, K. Aertgeerts, S. Curriden, and D. Loskutoff, Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins, The Journal of Cell Biology, vol.82, issue.5, pp.781-791, 2003.
DOI : 10.1074/jbc.275.22.16779

L. Staiano-coico, K. Carano, V. Allan, M. Steiner, I. Pagan-charry et al., PAI-1 Gene Expression Is Growth State-Regulated in Cultured Human Epidermal Keratinocytes during Progression to Confluence and Postwounding, Experimental Cell Research, vol.227, issue.1, pp.123-134, 1996.
DOI : 10.1006/excr.1996.0257

P. Bornstein, A. Agah, and T. Kyriakides, The role of thrombospondins 1 and 2 in the regulation of cell???matrix interactions, collagen fibril formation, and the response to injury, The International Journal of Biochemistry & Cell Biology, vol.36, issue.6, pp.1115-1125, 2004.
DOI : 10.1016/j.biocel.2004.01.012

T. Kyriakides and P. Bornstein, Matricellular proteins as modulators of wound healing and the foreign body response, Thrombosis and Haemostasis, vol.90, pp.986-992, 2003.
DOI : 10.1160/TH03-06-0399

P. Bornstein and E. Sage, Matricellular proteins: extracellular modulators of cell function, Current Opinion in Cell Biology, vol.14, issue.5, pp.608-616, 2002.
DOI : 10.1016/S0955-0674(02)00361-7

J. Varela, M. Goldstein, H. Baker, and G. Schultz, Microarray analysis of gene expression patterns during healing of rat corneas after excimer laser photorefractive keratectomy, Invest Ophthalmol Vis Sci, vol.43, pp.1772-1782, 2002.

D. Rosso, M. Anichini, E. Pedersen, N. Blasi, F. Fibbi et al., Urokinase-urokinase receptor interaction: non-mitogenic signal transduction in human epidermal cells, Biochem Biophys Res Commun, vol.190, pp.347-352, 1993.

L. Ossowski and J. Aguirre-ghiso, Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth, Current Opinion in Cell Biology, vol.12, issue.5, pp.613-620, 2000.
DOI : 10.1016/S0955-0674(00)00140-X

Z. Ma, K. Thomas, D. Webb, R. Moravec, A. Salicioni et al., Regulation of Rac1 activation by the low density lipoprotein receptor???related protein, The Journal of Cell Biology, vol.78, issue.6, pp.1061-1070, 2002.
DOI : 10.1074/jbc.271.46.29393

S. Carlin, T. Resink, M. Tamm, and M. Roth, Urokinase signal transduction and its role in cell migration, The FASEB Journal, vol.19, issue.2, pp.195-202, 2005.
DOI : 10.1096/fj.04-1644com