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PHMPL: a computer program for hazard estimation using a penalized likelihood method with interval-censored and left-truncated data.

Abstract : The Cox model is the model of choice when analyzing right-censored and possibly left-truncated survival data. The present paper proposes a program to estimate the hazard function in a proportional hazards model and also to treat more complex observation schemes involving general censored and left-truncated data. The hazard function estimator is defined non-parametrically as the function which maximizes a penalized likelihood, and the solution is approximated using splines. The smoothing parameter is chosen using approximate cross-validation. Confidence bands for the estimator are given. As an illustration, the age-specific incidence of dementia is estimated and one of its risk factors is studied.
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https://www.hal.inserm.fr/inserm-00182450
Contributor : Evelyne Mouillet <>
Submitted on : Friday, October 26, 2007 - 9:34:00 AM
Last modification on : Wednesday, November 29, 2017 - 2:54:49 PM
Long-term archiving on: : Monday, April 12, 2010 - 12:44:03 AM

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  • HAL Id : inserm-00182450, version 1
  • PUBMED : 10579515

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Pierre Joly, Luc Letenneur, Ahmadou Alioum, Daniel Commenges. PHMPL: a computer program for hazard estimation using a penalized likelihood method with interval-censored and left-truncated data.. Computer Methods and Programs in Biomedicine, Elsevier, 1999, 60 (3), pp.225-31. ⟨inserm-00182450⟩

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