Skip to Main content Skip to Navigation
Journal articles

Cross-sectional association between homocysteine and motor function in the elderly.

Abstract : OBJECTIVE: To determine if there is a cross-sectional association between homocysteine (tHcy) level and measures of gait and balance in elderly subjects. METHODS: We studied 3,609 noninstitutionalized subjects aged 65 to 85 years from the Dijon (France) center of the Three-City Study. tHcy concentration was measured from fasting blood samples. Motor function was assessed by measuring walking speed and by using a modified version of the Tinetti scale. RESULTS: After adjustment for confounders, mean maximum walking speed (MWS) decreased with increasing tHcy levels (p = 0.001). The odds ratio (OR) (95% CI) for having a MWS below the 40th percentile was 1.9 (1.4 to 2.5) in subjects with tHcy levels in the upper quintile compared with those in the lowest quintile. Compared with subjects in the lowest tHcy quintile, the OR for having a modified Tinetti score below 16 ranged from 1.0 (0.8 to 1.4) in the second quintile to 1.9 (1.3 to 2.6) in the upper quintile (p < 0.0001). CONCLUSIONS: Elevated homocysteine concentrations are associated with worse motor performances in the elderly. These findings support the hypothesis of a vascular contribution to motor function.
Complete list of metadata

Cited literature [28 references]  Display  Hide  Download
Contributor : Christophe Tzourio <>
Submitted on : Wednesday, October 17, 2007 - 3:19:26 PM
Last modification on : Monday, December 14, 2020 - 9:56:28 AM
Long-term archiving on: : Friday, November 25, 2016 - 7:07:24 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Amady Soumaré, Alexis Elbaz, Véronique Ducros, Béatrice Tavernier, Annick Alpérovitch, et al.. Cross-sectional association between homocysteine and motor function in the elderly.. Neurology, American Academy of Neurology, 2006, 67 (6), pp.985-90. ⟨10.1212/01.wnl.0000237325.16502.08⟩. ⟨inserm-00180043⟩



Record views