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Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004.: HBV genotypes in Southwestern France

Abstract : OBJECTIVE: To determine the prevalence of HBV genotypes in Southwestern France and the association between HBV genotypes and patients characteristics.METHODS: 194 HBsAg-positive patients (median age: 45 yrs, range: 7-77, male: 78%) followed in Bordeaux Hospital in 1999-2004 were included. HBV genotype, pre-core (PC) and core promoter (CP) mutations were determined by sequencing.RESULTS: Genotype distribution was A 51%, B 6.7%, C 5.7%, D 26.3%, E 7.7%, F 0.5%, G 2.1%. Among the 146 patients documented, 71.2% were Caucasians, 15.8% Africans, 13.0% Asians. Fifty-seven patients (36%) were HIV-infected. Eighty-two (42.3%) patients were HBeAg-positive. Genotype A was almost exclusively carried by Caucasians (96%), Africans were most frequent among genotype E (82%), and Asians were most prevalent among genotypes B and C (82% and 80%, respectively). Genotype A was associated with a higher prevalence of HBeAg than genotype D (53% versus 35.3%, P=0.03). PC variant was detected in 35% and CP variant in 43% of patients. PC variant was uncommon in genotype A patients (7.3%).CONCLUSION: Distribution of HBV genotypes differs according to ethnic origin, genotypes A and D being the most frequently found. Genotype A was more frequently associated with HBeAg-positivity and genotype D with HBeAg-negativity.
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https://www.hal.inserm.fr/inserm-00177752
Contributor : Evelyne Mouillet <>
Submitted on : Wednesday, January 9, 2008 - 1:54:41 PM
Last modification on : Wednesday, November 29, 2017 - 2:54:41 PM
Long-term archiving on: : Sunday, April 11, 2010 - 10:32:08 PM

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  • HAL Id : inserm-00177752, version 1
  • PUBMED : 18176363

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Pascale Trimoulet, Mathieu Boutonnet, Maria Winnock, Muriel Faure, Marc-Arthur Loko, et al.. Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004.: HBV genotypes in Southwestern France. Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, Elsevier Masson, 2007, 31 (12), pp.1088-94. ⟨inserm-00177752⟩

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