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Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.

Abstract : Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).
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https://www.hal.inserm.fr/inserm-00177234
Contributor : Christophe Tzourio <>
Submitted on : Friday, October 5, 2007 - 6:13:45 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:02 AM
Long-term archiving on: : Friday, November 25, 2016 - 5:36:05 PM

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Michael Schüpbach, Marie-Laure Welter, Anne-Marie Bonnet, Alexis Elbaz, Brandon Grossardt, et al.. Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.. Movement Disorders, Wiley, 2007, 22 (2), pp.257-61. ⟨10.1002/mds.21264⟩. ⟨inserm-00177234⟩

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