Skip to Main content Skip to Navigation
Journal articles

[Parkinson's disease and rural environment]

Alexis Elbaz 1, *
* Corresponding author
Abstract : Parkinson's disease, the primary cause of parkinsonian syndrome, is, after Alzheimer's disease, the most frequent neurodegenerative disorder. Parkinson's disease is currently considered as a multifactorial disease resulting from the effect of genetic and environmental susceptibility. Several epidemiological studies have shown a moderate association between Parkinson's disease and farmer occupation or exposure to pesticides. Nevertheless, no product has been incriminated in a repeatable manner in these studies. The main methodological difficulty of these studies is associated with the complexity in assessing the occupational exposure to pesticides. The results of the toxicological studies point equally in this direction and provide arguments in favor of this relationship. However, some questions remain to be answered, particularly the role of low-dose exposure, the gene-environment interactions and the implied biological mechanisms.
Complete list of metadatas

Cited literature [6 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00177222
Contributor : Christophe Tzourio <>
Submitted on : Friday, October 5, 2007 - 5:44:33 PM
Last modification on : Sunday, December 9, 2018 - 1:26:24 AM
Long-term archiving on: : Friday, November 25, 2016 - 5:09:16 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

  • HAL Id : inserm-00177222, version 1
  • PUBMED : 17708091

Collections

Citation

Alexis Elbaz. [Parkinson's disease and rural environment]. Revue du Praticien (La), J B Bailliere et Fils, 2007, 57 (11 Suppl), pp.37-9. ⟨inserm-00177222⟩

Share

Metrics

Record views

75