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Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.

Alexis Elbaz 1 Lorene Nelson 2 Haydeh Payami 3 John Ioannidis 4 Brian Fiske 5, * Grazia Annesi 6 Andrea Carmine Belin 7 Stewart Factor 8 Carlo Ferrarese 9 Georgios Hadjigeorgiou 10 Donald Higgins 11 Hideshi Kawakami 12 Rejko Krüger 13 Karen Marder 14 Richard Mayeux 14 George Mellick 15 John Nutt 16 Beate Ritz 17 Ali Samii 18 Caroline Tanner 19 Christine van Broeckhoven 20 Stephen van den Eeden 21 Karin Wirdefeldt 22 Cyrus Zabetian 23, 24 Marie Dehem 25 Jennifer Montimurro 3 Audrey Southwick 26 Richard Myers 26 Thomas Trikalinos 4
Abstract : BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. METHODS: Investigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies. FINDINGS: In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0.89 to 1.09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0.95 to 1.08); there was little heterogeneity except for SNP rs7520966. INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.
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Submitted on : Wednesday, October 17, 2007 - 1:02:44 PM
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Alexis Elbaz, Lorene Nelson, Haydeh Payami, John Ioannidis, Brian Fiske, et al.. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.. The Lancet Neurology, Elsevier, 2006, 5 (11), pp.917-23. ⟨10.1016/S1474-4422(06)70579-8⟩. ⟨inserm-00177203⟩



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