R. A. Anderson, A. M. Roussel, N. Zouari, S. Mahjoub, J. M. Matheau et al., Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus, Journal of the American College of Nutrition, vol.5, issue.3, pp.212-218, 2001.
DOI : 10.1080/07315724.2001.10719034

J. W. Baynes, Role of Oxidative Stress in Development of Complications in Diabetes, Diabetes, vol.40, issue.4, pp.405-412, 1991.
DOI : 10.2337/diab.40.4.405

M. Bjornholm and J. R. Zierath, Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes: Figure 1, Biochemical Society Transactions, vol.33, issue.2, pp.354-357, 2005.
DOI : 10.1042/BST0330354

A. Bloc, T. Cens, H. Cruz, and Y. Dunant, channels, The Journal of Physiology, vol.49, issue.3, pp.723-734, 2000.
DOI : 10.1111/j.1469-7793.2000.00723.x

J. Carmichael, W. G. Degraff, A. F. Gazdar, J. D. Minna, and J. B. Mitchell, Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing, Cancer Res, vol.47, pp.936-942, 1987.

J. Chandra, B. Zhivotovsky, S. Zaitsev, L. Juntti-berggren, P. O. Berggren et al., Role of apoptosis in pancreatic beta-cell death in diabetes, Diabetes, vol.50, issue.Supplement 1, pp.44-47, 2001.
DOI : 10.2337/diabetes.50.2007.S44

A. B. Chausmer, Zinc, Insulin and Diabetes, Journal of the American College of Nutrition, vol.49, issue.2, pp.109-115, 1998.
DOI : 10.1080/07315724.1998.10718735

M. D. Chen, Y. M. Song, and P. Y. Lin, Zinc Effects on Hyperglycemia and Hypoleptinemia in Streptozotocin-Induced Diabetic Mice, Hormone and Metabolic Research, vol.32, issue.03, pp.107-109, 2000.
DOI : 10.1055/s-2007-978600

F. Chimienti, M. Seve, S. Richard, J. Mathieu, and A. Favier, Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors11Abbreviations: Chx, cycloheximide; PARP, poly(ADP-ribose) polymerase; TNF??, tumor necrosis factor alpha; and TPEN: N,N,N???,N???-tetrakis(2-pyridylmethyl)ethylenediamine., Biochemical Pharmacology, vol.62, issue.1, pp.51-62, 2001.
DOI : 10.1016/S0006-2952(01)00624-4

F. Chimienti, M. Aouffen, A. Favier, and M. Seve, Zinc Homeostasis-regulating Proteins: New Drug Targets for Triggering Cell Fate, Current Drug Targets, vol.4, issue.4, pp.323-338, 2003.
DOI : 10.2174/1389450033491082

F. Chimienti, S. Devergnas, A. Favier, and M. Seve, Identification and Cloning of a ??-Cell-Specific Zinc Transporter, ZnT-8, Localized Into Insulin Secretory Granules, Diabetes, vol.53, issue.9, pp.2330-2337, 2004.
DOI : 10.2337/diabetes.53.9.2330

K. S. Clifford and M. J. Macdonald, Survey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague???Dawley and Wistar BB strains, Diabetes Research and Clinical Practice, vol.49, issue.2-3, pp.77-85, 2000.
DOI : 10.1016/S0168-8227(00)00141-8

L. C. Costello, P. Feng, B. Milon, M. Tan, and R. B. Franklin, Role of zinc in the pathogenesis and treatment of prostate cancer: critical issues to resolve, Prostate Cancer and Prostatic Diseases, vol.7, issue.2, pp.111-117, 2004.
DOI : 10.1038/sj.pcan.4500712

J. T. Deeney, M. Prentki, and B. E. Corkey, Metabolic control of??-cell function, Seminars in Cell & Developmental Biology, vol.11, issue.4, pp.267-275, 2000.
DOI : 10.1006/scdb.2000.0175

R. A. Defronzo, R. Gunnarsson, O. Bjorkman, M. Olsson, and J. Wahren, Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus., Journal of Clinical Investigation, vol.76, issue.1, pp.149-155, 1985.
DOI : 10.1172/JCI111938

R. A. Defronzo, R. C. Bonadonna, and E. Ferrannini, Pathogenesis of NIDDM: A Balanced Overview, Diabetes Care, vol.15, issue.3, pp.318-368, 1992.
DOI : 10.2337/diacare.15.3.318

S. Devergnas, F. Chimienti, N. Naud, A. Pennequin, Y. Coquerel et al., Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT???PCR study, Biochemical Pharmacology, vol.68, issue.4, pp.699-709, 2004.
DOI : 10.1016/j.bcp.2004.05.024

G. Dodson and D. Steiner, The role of assembly in insulin's biosynthesis, Current Opinion in Structural Biology, vol.8, issue.2, pp.189-194, 1998.
DOI : 10.1016/S0959-440X(98)80037-7

S. O. Emdin, G. G. Dodson, J. M. Cutfield, and S. M. Cutfield, Role of zinc in insulin biosynthesis, Diabetologia, vol.103, issue.3, pp.174-182, 1980.
DOI : 10.1007/BF00275265

K. Engelbart and H. Kief, The functional behaviour of zinc and insulin contained in the pancreatic beta-cells of rats, Virchows Arch. B Cell Pathol, vol.4, pp.294-302, 1970.

D. P. Figlewicz, S. E. Forhan, A. T. Hodgson, and G. M. Grodsky, Zinc and Endogenous Zinc Content and Distribution in Islets in Relationship to Insulin Content*, Endocrinology, vol.115, issue.3, pp.877-881, 1984.
DOI : 10.1210/endo-115-3-877

C. J. Frederickson, J. Y. Koh, and A. I. Bush, The neurobiology of zinc in health and disease, Nature Reviews Neuroscience, vol.69, issue.6, pp.449-462, 2005.
DOI : 10.1111/j.1469-7793.1998.363bw.x

V. K. Garg, R. Gupta, and R. K. Goyal, Hypozincemia in diabetes mellitus, J. Assoc. Physicians India, vol.42, pp.720-721, 1994.

T. Hirokawa, S. Boon-chieng, and S. Mitaku, SOSUI: classification and secondary structure prediction system for membrane proteins, Bioinformatics, vol.14, issue.4, pp.378-379, 1998.
DOI : 10.1093/bioinformatics/14.4.378

E. Ho, N. Quan, Y. H. Tsai, W. Lai, and T. M. Bray, Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice, Exp. Biol. Med. Maywood, vol.226, pp.103-111, 2001.

B. B. Kahn, Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance, Cell, vol.92, issue.5, pp.593-596, 1998.
DOI : 10.1016/S0092-8674(00)81125-3

T. Kambe, H. Narita, Y. Yamaguchi-iwai, J. Hirose, T. Amano et al., Cloning and Characterization of a Novel Mammalian Zinc Transporter, Zinc Transporter 5, Abundantly Expressed in Pancreatic beta Cells, Journal of Biological Chemistry, vol.277, issue.21, pp.19049-19055, 2002.
DOI : 10.1074/jbc.M200910200

T. Kambe, Y. Yamaguchi-iwai, R. Sasaki, and M. Nagao, Overview of mammalian zinc transporters, Cellular and Molecular Life Sciences (CMLS), vol.61, issue.1, pp.49-68, 2004.
DOI : 10.1007/s00018-003-3148-y

B. J. Kim, Y. H. Kim, S. Kim, J. W. Kim, J. Y. Koh et al., Zinc as a paracrine effector in pancreatic islet cell death, Diabetes, vol.49, issue.3, pp.367-372, 2000.
DOI : 10.2337/diabetes.49.3.367

B. Lukowiak, B. Vandewalle, R. Riachy, J. Kerr-conte, V. Gmyr et al., Identification and Purification of Functional Human ??-cells by a New Specific Zinc-fluorescent Probe, Journal of Histochemistry & Cytochemistry, vol.296, issue.4, pp.519-528, 2001.
DOI : 10.1177/42.7.8014471

W. R. Mathews, F. Wang, D. J. Eide, and M. Van-doren, Drosophila fear of intimacy Encodes a Zrt/IRT-like Protein (ZIP) Family Zinc Transporter Functionally Related to Mammalian ZIP Proteins, Journal of Biological Chemistry, vol.280, issue.1, pp.787-795, 2005.
DOI : 10.1074/jbc.M411308200

A. Merglen, S. Theander, B. Rubi, G. Chaffard, C. B. Wollheim et al., Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells, Endocrinology, vol.145, issue.2, pp.667-678, 2004.
DOI : 10.1210/en.2003-1099

A. A. Michalczyk, J. Allen, R. C. Blomeley, and M. L. Ackland, Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells, Biochemical Journal, vol.364, issue.1, pp.105-113, 2002.
DOI : 10.1042/bj3640105

W. J. Qian, C. A. Aspinwall, M. A. Battiste, and R. T. Kennedy, Detection of Secretion from Single Pancreatic ??-Cells Using Extracellular Fluorogenic Reactions and Confocal Fluorescence Microscopy, Analytical Chemistry, vol.72, issue.4, pp.711-717, 2000.
DOI : 10.1021/ac991085t

J. Quarterman, C. F. Mills, and W. R. Humphries, The reduced secretion of, and sensitivity to insulin in zinc-deficient rats, Biochemical and Biophysical Research Communications, vol.25, issue.3, pp.354-358, 1966.
DOI : 10.1016/0006-291X(66)90785-6

A. M. Roussel, A. Kerkeni, N. Zouari, S. Mahjoub, J. M. Matheau et al., Antioxidant Effects of Zinc Supplementation in Tunisians with Type 2 Diabetes Mellitus, Journal of the American College of Nutrition, vol.81, issue.4, pp.316-321, 2003.
DOI : 10.1080/07315724.2003.10719310

G. A. Rutter, Nutrient???secretion coupling in the pancreatic islet ??-cell: recent advances, Molecular Aspects of Medicine, vol.22, issue.6, pp.247-284, 2001.
DOI : 10.1016/S0098-2997(01)00013-9

C. Sagne, M. F. Isambert, J. P. Henry, and B. Gasnier, SDS-resistant aggregation of membrane proteins: application to the purification of the vesicular monoamine transporter, Biochemical Journal, vol.316, issue.3, pp.825-831, 1996.
DOI : 10.1042/bj3160825

M. Seve, F. Chimienti, S. Devergnas, and A. Favier, In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression, BMC Genomics, vol.5, issue.1, p.32, 2004.
DOI : 10.1186/1471-2164-5-32

S. F. Simon and C. G. Taylor, Dietary zinc supplementation attenuates hyperglycemia in db/db mice, Exp. Biol. Med. Maywood, vol.226, pp.43-51, 2001.

L. G. Sondergaard, M. Stoltenberg, A. Flyvbjerg, B. Brock, O. Schmitz et al., Zinc ions in beta-cells of obese, insulin-resistant, and type 2 diabetic rats traced by autometallography, APMIS, vol.53, issue.12, pp.1147-1154, 2003.
DOI : 10.1016/S0303-7207(97)00220-7

L. G. Sondergaard, B. Brock, M. Stoltenberg, A. Flyvbjerg, O. Schmitz et al., Zinc Fluxes during Acute and Chronic Exposure of INS-1E Cells to Increasing Glucose Levels, Hormone and Metabolic Research, vol.37, issue.3, pp.133-139, 2005.
DOI : 10.1055/s-2005-861290

T. Suzuki, K. Ishihara, H. Migaki, W. Matsuura, A. Kohda et al., Zinc Transporters, ZnT5 and ZnT7, Are Required for the Activation of Alkaline Phosphatases, Zinc-requiring Enzymes That Are Glycosylphosphatidylinositol-anchored to the Cytoplasmic Membrane, Journal of Biological Chemistry, vol.280, issue.1, pp.637-643, 2005.
DOI : 10.1074/jbc.M411247200

C. G. Taylor, Zinc, the Pancreas, and Diabetes: Insights from Rodent Studies and Future Directions, BioMetals, vol.42, issue.7, pp.305-312, 2005.
DOI : 10.1007/s10534-005-3686-x

B. L. Vallee and K. H. Falchuk, The biochemical basis of zinc physiology, Physiol. Rev, vol.73, pp.79-118, 1993.

P. D. Zalewski, S. H. Millard, I. J. Forbes, O. Kapaniris, A. Slavotinek et al., Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc., Journal of Histochemistry & Cytochemistry, vol.42, issue.7, pp.877-884, 1994.
DOI : 10.1177/42.7.8014471