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Description of the local protein structure. II. Novel approaches.: structural alphabet

Abstract : The repetitive local structures, i.e. the alpha-helices and the beta-sheets have been widely used and analysed. However, they only describe 50% of the residues and sometimes roughly. So, other approaches have led to a new view of 3D protein structures. They are now thought to be composed of a combination of small local structures or fragments, also called prototypes. The complete set of prototypes defines “a structural alphabet.” Different teams have described these local protein structures according to different criteria. The structural alphabets have been used to approximate locally the protein structures, analyze them and also for prediction purposes. In this review, we present them from a historic point of view and focus on the most recent advances.
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Contributor : Alexandre G. de Brevern Connect in order to contact the contributor
Submitted on : Thursday, October 4, 2007 - 12:38:22 PM
Last modification on : Tuesday, May 17, 2022 - 2:58:09 PM
Long-term archiving on: : Friday, November 25, 2016 - 5:53:26 PM


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  • HAL Id : inserm-00176668, version 1
  • PRODINRA : 251232


Manoj Tyagi, Cristina Benros, Juliette Martin, Alexandre de Brevern. Description of the local protein structure. II. Novel approaches.: structural alphabet. Alexandre G. de Brevern. Recent Advances in Structural Bioinformatics, Research Signpost, Trivandrum, Kerala, India., pp.28-42, 2007. ⟨inserm-00176668⟩



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