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Alveolar bone regeneration for immediate implant placement using an injectable bone substitute: an experimental study in dogs.

Abstract : BACKGROUND: The aim of the present study was to assess the efficacy of a ready-to-use injectable bone substitute for bone regeneration around dental implants placed into fresh extraction sockets. METHODS: Third and fourth mandibular premolars were extracted from three beagle dogs and the interradicular septa were surgically reduced to induce a mesial bone defect. Thereafter, titanium implants were immediately placed. On the left side of the jaw, mesial bone defects were filled with an injectable bone substitute (IBS), obtained by combining a polymer and biphasic calcium phosphate ceramic granules. The right defects were left unfilled as controls. After 3 months of healing, specimens were prepared for histological and histomorphometric evaluations. RESULTS: No post-surgical complications were observed during the healing period. In all experimental conditions, histological observations revealed a lamellar bone formation in contact with the implant. Histomorphometric analysis showed that IBS triggers a significant (P<0.05) increase in terms of the number of threads in contact with bone, bone-to-implant contact, and peri-implant bone density of approximately 8.6%, 11.0%, and 14.7%, respectively. In addition, no significant difference was observed when number of threads, bone-to-implant contact, and bone density in the filled defects were compared to the no-defect sites. CONCLUSION: It is concluded that an injectable bone substitute composed of a polymeric carrier and calcium phosphate significantly increases bone regeneration around immediately placed implants.
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https://www.hal.inserm.fr/inserm-00176539
Contributor : Pierre Weiss <>
Submitted on : Monday, June 23, 2014 - 1:50:36 PM
Last modification on : Thursday, April 5, 2018 - 10:36:36 AM
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Damien Boix, Olivier Gauthier, Jérôme Guicheux, Paul Pilet, Pierre Weiss, et al.. Alveolar bone regeneration for immediate implant placement using an injectable bone substitute: an experimental study in dogs.. Journal of periodontology, American Academy of Periodontology, 2004, 75 (5), pp.663-71. ⟨inserm-00176539⟩

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