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Light scattering experiments on aqueous solutions of selected cellulose ethers: contribution to the study of polymer-mineral interactions in a new injectable biomaterial.

Abstract : Hydroxypropylmethylcellulose (HPMC) is used as a ligand for a bioactive calcium phosphate ceramic (the filler) in a ready-to-use injectable sterilized biomaterial for bone and dental surgery. Light scattering experiments were usually used to study high water-soluble polymers and to determine the basic macromolecular parameters. In order to gain a deeper understanding of polymer/mineral interactions in this type of material, we have investigated the effect of divalent and trivalent ions (Ca(2+), PO(4)(3-)) and steam sterilization on dilute solutions of HPMC and hydroxyethylcellulose (HEC). The sterilization process may cause some degradation of HEC taking into account its high molecular weight and some rigidity of the polymer chain. Moreover, in the case of HPMC, the changes in the conformations rather than degradation process are supposed. These effects of degradation and flocculation are strengthened in alkaline medium. Experimental data suggested the formation of chelate complexes between Ca(2+) and HPMC which improve its affinity to the mineral blend and consolidate the injectable biomaterial even in the case of its hydration by biological fluid.
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https://www.hal.inserm.fr/inserm-00176536
Contributor : Pierre Weiss <>
Submitted on : Wednesday, October 3, 2007 - 9:35:22 PM
Last modification on : Sunday, May 31, 2020 - 6:59:04 PM
Long-term archiving on: : Thursday, September 27, 2012 - 12:42:33 PM

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  • HAL Id : inserm-00176536, version 1
  • PUBMED : 15348303
  • PRODINRA : 251231

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Sylvain Bohic, Pierre Weiss, Philippe Roger, Guy Daculsi. Light scattering experiments on aqueous solutions of selected cellulose ethers: contribution to the study of polymer-mineral interactions in a new injectable biomaterial.. Journal of Materials Science: Materials in Medicine, Springer Verlag, 2001, 12 (3), pp.201-5. ⟨inserm-00176536⟩

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