Skip to Main content Skip to Navigation
Journal articles

[Acute and long-term effects of ecstasy]

Abstract : Side effects in the short term Recreational use of Ecstasy (3,4-methylenedioxymethamphetamine or MDMA), a synthetic drug, has considerably increased over the last decade. Since its appearance it is associated with the rave culture, but its use has spread to other social settings. The drug produces euphoria and empathy, but can lead to side effects, notably acute, potentially lethal, toxicity (malignant hyperthermia and/or hepatitis). Neurotoxicity in the long-term Moreover, MDMA has been shown to induce long-term deleterious effects and provoke neurotoxic affecting the serotoninergic system. However, the psychopathological consequences of such neurotoxicity are still controversial, particularly since many ecstasy consumers are multi-drug users. A complex pharmacological profile The mechanism of action of MDMA involves various neurobiological systems (serotonin, dopamine, noradrenalin), that may all interact.
Document type :
Journal articles
Complete list of metadatas
Contributor : Cynthia Marie-Claire <>
Submitted on : Tuesday, October 2, 2007 - 5:19:11 PM
Last modification on : Wednesday, October 14, 2020 - 3:59:26 AM
Long-term archiving on: : Friday, November 25, 2016 - 7:23:14 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document


  • HAL Id : inserm-00176174, version 1
  • PUBMED : 15617173


Julie Salzmann, Cynthia Marie-Claire, Florence Noble. [Acute and long-term effects of ecstasy]. La Presse Médicale, Elsevier Masson, 2004, 33 (18 Suppl), pp.24-32. ⟨inserm-00176174⟩



Record views