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Article Dans Une Revue Autophagy Année : 2007

AMP-activated protein kinase and autophagy.

Résumé

Autophagy is inhibited by TOR-dependent signaling. Interruption of signalling by rapamycin is known to stimulate autophagy, both in mammalian cells and in yeast. However, inactivation of TOR by AMPK has yielded controversial results in the literature with regard to its effect on autophagy: activation of autophagy in yeast but inhibition in hepatocytes. In a recent study, carried out with hepatocytes, HT-29 cells, and HeLa cells, the possible role of AMPK in the control of mammalian autophagy was reexamined. The data suggest that in mammalian cells, as in yeast, AMPK is required for autophagy.
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Dates et versions

inserm-00175293 , version 1 (19-03-2012)

Identifiants

  • HAL Id : inserm-00175293 , version 1
  • PUBMED : 17224623

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Alfred J. Meijer, Patrice Codogno. AMP-activated protein kinase and autophagy.. Autophagy, 2007, 3 (3), pp.238-40. ⟨inserm-00175293⟩
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