Skip to Main content Skip to Navigation
Journal articles

Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species.

Abstract : The NF-kappaB transcription factor is an important anti-apoptotic factor, which is frequently deregulated in cancer cells. We have recently demonstrated that NF-kappaB activation mediates the repression of autophagy in response to TNFa in three models of cancer cell lines. In contrast, in the absence of NF-kappaB activation, TNFa induces macroautophagy (autophagy), which requires reactive oxygen species (ROS) production and participates in the TNFalpha-induced apoptotic signaling pathway. Autophagy-dependent apoptosis was also observed following direct addition of ROS to cells. Moreover, addition of rapamycin to TNFalpha renders these cells susceptible to the cytotoxic effect of this cytokine. These findings highlight the regulation of autophagy by oxidative stress and support the idea that repression of autophagy by NF-kappaB may constitute a novel anti-apoptotic function of this transcription factor. We also bring evidence that direct stimulation of autophagy may represent a new therapeutic strategy for overcoming the NF-kappaB-dependent chemoresistance of cancer cells.
Document type :
Journal articles
Complete list of metadatas

Cited literature [15 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00175265
Contributor : Patrice Codogno <>
Submitted on : Monday, March 19, 2012 - 11:00:00 AM
Last modification on : Wednesday, September 16, 2020 - 4:56:01 PM
Long-term archiving on: : Wednesday, June 20, 2012 - 2:20:34 AM

Identifiers

  • HAL Id : inserm-00175265, version 1
  • PUBMED : 17471012

Collections

Citation

Mojgan Djavaheri-Mergny, Manuella Amelotti, Julie Mathieu, Francoise Besançon, Chantal Bauvy, et al.. Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species.. Autophagy, Taylor & Francis, 2007, 3 (4), pp.390-2. ⟨inserm-00175265⟩

Share

Metrics

Record views

230

Files downloads

1032