Skip to Main content Skip to Navigation
Journal articles

Morbidity before and after HAART initiation in Sub-Saharan African HIV-infected adults: a recurrent event analysis.: HIV morbidity recurrence in Abidjan

Abstract : The incidence and determinants of severe morbidity recurrence in sub-Saharan African HIV-infected adults on antiretroviral therapy (ART) have never been reported. In a prospective cohort study of HIV-infected adults in Abidjan the association of severe morbidity occurrence and recurrence with follow-up CD4 counts and ART on/off status was analyzed by means of multivariate failure analysis for recurrent events (Prentice, Williams, and Peterson model). A total of 608 patients (median CD4 290/mm3 ) was followed off ART for 1824 person-years (PY). Of these 187 started HAART (median CD4 174/mm3 ) and were followed for 328 PY. The incidence of first, second, and third severe morbidity events was 40.6/100 PY, 68.4/100 PY, and 93.9/100 PY during the off-ART period, and 28.4/100 PY, 39.4/100 PY, and 37.6/100 PY during the on-ART period, respectively. The rates of recurrences were higher than the rates of first episodes for almost all diseases, even after stratifying by CD4 count and by ART on/off status. In multivariate analysis, the time-updated CD4 count was independently associated with increasing rates of morbidity first events and recurrences, after adjustment on other covariates (p > 10(4) ). By contrast, there was no association between the ART on/off status and the morbidity rates after adjustment for CD4 count (p = 0.37). Introducing ART led to a clear reduction in morbidity, mainly related to the ART-induced increase in CD4 count. In HIV-infected patients on ART, the incidence of severe morbidity varied with the past history of morbidity. The past history of morbidity should be taken into account when comparing HIV morbidity rates before and after ART initiation.
Document type :
Journal articles
Complete list of metadatas

Cited literature [21 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00173538
Contributor : Evelyne Mouillet <>
Submitted on : Thursday, September 20, 2007 - 9:56:46 AM
Last modification on : Sunday, October 25, 2020 - 7:05:08 AM
Long-term archiving on: : Friday, November 25, 2016 - 6:34:15 PM

File

Seyler.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Catherine Seyler, Eugène Messou, Delphine Gabillard, André Inwoley, Ahmadou Alioum, et al.. Morbidity before and after HAART initiation in Sub-Saharan African HIV-infected adults: a recurrent event analysis.: HIV morbidity recurrence in Abidjan. AIDS Research and Human Retroviruses, Mary Ann Liebert, 2007, 23 (11), pp.1338-47. ⟨10.1089/aid.2006.0308⟩. ⟨inserm-00173538⟩

Share

Metrics

Record views

371

Files downloads

869