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Perioperative in-stent thrombosis after lung resection performed within 3 months of coronary stenting.

Abstract : BACKGROUND: Incidence of perioperative in-stent thrombosis associated with myocardial infarction in patients undergoing major lung resection within 3 months of coronary stenting. METHODS: Retrospective multi-institutional trial including all patients undergoing major lung resection (lobectomy or pneumonectomy) within 3 months of coronary stenting with non-drug-eluting stents between 1999 and 2004. RESULTS: There were 32 patients (29 men and 3 women), with age ranging from 46 to 82 years. One, two or four coronary stents were deployed in 72%, 22% and 6% of the patients, respectively. The time intervals between stenting and lung surgery were <30 days, 30-60 days and 61-90 days in 22%, 53% and 25% of the patients, respectively. All patients had dual antiplatelet therapy after stenting. Perioperative medication consisted of heparin alone or heparin plus aspirin in 34% and 66% of the patients, respectively. Perioperative in-stent thrombosis with myocardial infarction occurred in three patients (9%) with fatal outcome in one (3%). Twenty patients underwent lung resection after 4 weeks of dual antiplatelet therapy as recommended by the ACC/AHA Guideline Update; however, two out of three perioperative in-stent thrombosis occurred in this group of patients. CONCLUSIONS: Major lung resection performed within 3 months of coronary stenting may be complicated by perioperative in-stent thrombosis despite 4 weeks of dual antiplatelet therapy after stenting as recommended by the ACC/AHA Guideline Update.
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https://www.hal.inserm.fr/inserm-00173099
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Submitted on : Tuesday, September 18, 2007 - 5:49:36 PM
Last modification on : Thursday, July 25, 2019 - 2:24:50 PM

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Pierre-Yves Brichon, Philippe Boitet, Antoine Dujon, Jerôme Mouroux, Christophe Peillon, et al.. Perioperative in-stent thrombosis after lung resection performed within 3 months of coronary stenting.. European Journal of Cardio-Thoracic Surgery, Oxford University Press (OUP), 2006, 30 (5), pp.793-6. ⟨10.1016/j.ejcts.2006.08.012⟩. ⟨inserm-00173099⟩

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