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Syringotropic and pilotropic cutaneous T-cell lymphoma without follicular mucinosis

Abstract : BACKGROUND: Mycosis fongoides rarely exhibits predilection for infiltration of hair follicles and eccrine glands. We report the case of a patient with cutaneous T-cell lymphoma with syringotropism and pilotropism without follicular mucinosis. CASE REPORT: A 51-year-old man presented with erythematous infiltrated patches with alopecia and anhydrosis, cystic lesions, comedon-like lesions, follicular keratosis and an ulcer over the lower left leg. Clinical examination revealed no palpable adenopathy or hepatosplenomegaly. The patient complained about hypohydrosis. Histological examination of skin biopsies evidenced pilotropic cutaneous T-cell lymphoma without follicular mucinosis. Immunohistological examination and T-cell receptor B-chain gene rearrangement analysis showed a clonal population of T-cells. Moreover sweat glands and sweat ducts were infiltrated by atypical lymphocytes with syringolymphoid hyperplasia. DISCUSSION: Syringolymphoid hyperplasia and folliculotropism without follicular mucinosis are rarely seen in mycosis fongoides. Deep biopsies of adnexal structures are required for this critical diagnosis and clonal rearrangement of TCR genes is a reliable means of assessing clonality. Syringolymphoid hyperplasia and pilotropism without mucinosis are variants of cutaneous T-cell lymphomas.
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Contributor : Danielle Salas <>
Submitted on : Tuesday, September 18, 2007 - 5:29:24 PM
Last modification on : Thursday, August 27, 2020 - 11:36:03 AM


  • HAL Id : inserm-00173086, version 1
  • PUBMED : 17375013



Jérôme Charles, Sylvie Lantuejoul, Jl Reymond, E. Cuchet, J. Wechsler, et al.. Syringotropic and pilotropic cutaneous T-cell lymphoma without follicular mucinosis. Annales de Dermatologie et de Vénéréologie, Elsevier Masson, 2007, 134 (2), pp.155-9. ⟨inserm-00173086⟩



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