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Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle).

Abstract : Death of cancer cells influences tumor development and progression, as well as the response to anticancer therapies. This can occur through different cell death programmes which have recently been shown to implicate components of the acidic organelles, lysosomes. The role of lysosomes and lysosomal enzymes, including cathepsins and some lipid hydrolases, in programmed cell death associated with apoptotic or autophagic phenotypes is presented, as evidenced from observations on cultured cells and living animals. The possible molecular mechanisms that underlie the action of lysosomes during cell death are also described. Finally, the contribution of lysosomal proteins and lysosomes to tumor initiation and progression is discussed. Elucidation of this role and the underlying mechanisms will shed a new light on these 'old' organelles and hopefully pave the way for the development of novel anticancer strategies.
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Contributor : Patrice Codogno Connect in order to contact the contributor
Submitted on : Friday, September 14, 2007 - 4:20:29 PM
Last modification on : Monday, July 4, 2022 - 8:52:17 AM
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Claudine Tardy, Patrice Codogno, Hélène Autefage, Thierry Levade, Nathalie Andrieu-Abadie. Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle).. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 2006, 1765 (2), pp.101-25. ⟨10.1016/j.bbcan.2005.11.003⟩. ⟨inserm-00172288⟩



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