Autophagy and signaling: their role in cell survival and cell death.

Abstract : Macroautophagy is a vacuolar, self-digesting mechanism responsible for the removal of long-lived proteins and damaged organelles by the lysosome. The discovery of the ATG genes has provided key information about the formation of the autophagosome, and about the role of macroautophagy in allowing cells to survive during nutrient depletion and/or in the absence of growth factors. Two connected signaling pathways encompassing class-I phosphatidylinositol 3-kinase and (mammalian) target of rapamycin play a central role in controlling macroautophagy in response to starvation. However, a considerable body of literature reports that macroautophagy is also a cell death mechanism that can occur either in the absence of detectable signs of apoptosis (via autophagic cell death) or concomitantly with apoptosis. Macroautophagy is activated by signaling pathways that also control apoptosis. The aim of this review is to discuss the signaling pathways that control macroautophagy during cell survival and cell death.
Document type :
Journal articles
Complete list of metadatas

Cited literature [88 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00172272
Contributor : Patrice Codogno <>
Submitted on : Friday, September 14, 2007 - 3:34:09 PM
Last modification on : Thursday, February 9, 2017 - 4:00:35 PM
Long-term archiving on: Friday, November 25, 2016 - 5:24:53 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Patrice Codogno, Alfred Meijer. Autophagy and signaling: their role in cell survival and cell death.. Cell Death and Differentiation, Nature Publishing Group, 2005, 12 Suppl 2, pp.1509-18. ⟨10.1038/sj.cdd.4401751⟩. ⟨inserm-00172272⟩

Share

Metrics

Record views

205