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Autophagy and caspase-independent cell death: p19ARF enters the game.

Abstract : ARF, often localized in the nucleolus, controls the p53 pathway and ribosomal biogenesis. In a recent issue of Molecular Cell, Kimchi and colleagues describe a short mitochondrial form of ARF (smARF), produced by internal initiation of translation, that dissipates mitochondrial membrane potential independently of p53 and Bcl-2 family members and triggers caspase-independent cell death. The prodeath function of smARF is dependent on the induction of autophagy.
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Contributor : Patrice Codogno <>
Submitted on : Friday, September 14, 2007 - 12:06:17 PM
Last modification on : Wednesday, September 16, 2020 - 4:54:59 PM
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Patrice Codogno. Autophagy and caspase-independent cell death: p19ARF enters the game.. Developmental Cell, Elsevier, 2006, 10 (6), pp.688-9. ⟨10.1016/j.devcel.2006.05.003⟩. ⟨inserm-00172140⟩



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