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Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?

Abstract : Sphingolipids are major constituents of biological membrane and some of them behave as second messengers involved in the cell fate decision. Ceramide and sphingosine 1-phosphate (S1P) constitute a rheostat system in which ceramide promotes cell death and S1P increases cell survival. We have shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival. Here we discuss and speculate on the diverging functions of the autophagic pathways induced by ceramide and S1P, respectively.
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https://www.hal.inserm.fr/inserm-00172116
Contributor : Patrice Codogno <>
Submitted on : Monday, March 19, 2012 - 10:58:32 AM
Last modification on : Monday, October 12, 2020 - 10:27:47 AM
Long-term archiving on: : Wednesday, June 20, 2012 - 2:20:27 AM

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  • HAL Id : inserm-00172116, version 1
  • PUBMED : 17035732

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Gregory Lavieu, Francesca Scarlatti, Giusy Sala, Thierry Levade, Riccardo Ghidoni, et al.. Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?. Autophagy, Taylor & Francis, 2007, 3 (1), pp.45-7. ⟨inserm-00172116⟩

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