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Atg5: more than an autophagy factor.

Abstract : Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in addition ot its role in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.
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Contributor : Patrice Codogno <>
Submitted on : Friday, September 14, 2007 - 10:16:16 AM
Last modification on : Wednesday, September 16, 2020 - 4:54:59 PM
Long-term archiving on: : Friday, November 25, 2016 - 4:49:26 PM


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Patrice Codogno, Alfred Meijer. Atg5: more than an autophagy factor.. Nature Cell Biology, Nature Publishing Group, 2006, 8 (10), pp.1045-7. ⟨10.1038/ncb1006-1045⟩. ⟨inserm-00172087⟩



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