J. A. Keelan, K. W. Marvin, T. A. Sato, M. Coleman, L. M. Mccowan et al., Cytokine abundance in placental tissues: Evidence of inflammatory activation in gestational membranes with term and preterm parturition, American Journal of Obstetrics and Gynecology, vol.181, issue.6, pp.1530-1536, 1999.
DOI : 10.1016/S0002-9378(99)70400-X

B. M. Mercer, Preterm premature rupture of the membranes, Obstet. Gynecol, vol.101, pp.178-193, 2003.

J. A. Keelan, M. Blumenstein, R. J. Helliwell, T. A. Sato, K. W. Marvin et al., Cytokines, Prostaglandins and Parturition???A Review, Placenta, vol.24, pp.33-46, 2003.
DOI : 10.1053/plac.2002.0948

N. Athayde, S. S. Edwin, R. Romero, R. Gomez, E. Maymon et al., A role for matrix metalloproteinase-9 in spontaneous rupture of the fetal membranes, American Journal of Obstetrics and Gynecology, vol.179, issue.5, pp.1248-1253, 1998.
DOI : 10.1016/S0002-9378(98)70141-3

F. Arechavaleta-velasco, D. Ogando, S. Parry, and F. Vadillo-ortega, Production of Matrix Metalloproteinase-9 in Lipopolysaccharide-Stimulated Human Amnion Occurs Through an Autocrine and Paracrine Proinflammatory Cytokine-Dependent System1, Biology of Reproduction, vol.67, issue.6, pp.1952-1958, 2002.
DOI : 10.1095/biolreprod.102.004721

M. S. Trautman, D. Collmer, S. S. Edwin, W. White, M. D. Mitchell et al., Expression of Interleukin-10 in Human Gestational Tissues, Journal of the Society for Gynecologic Investigation, vol.4, issue.5, pp.247-253, 1997.
DOI : 10.1016/S1071-5576(97)00045-2

K. W. Moore, A. O. Garra, R. De-waal-malefyt, P. Vieira, and T. R. Mosmann, Interleukin-10, Annual Review of Immunology, vol.11, issue.1, pp.165-190, 1993.
DOI : 10.1146/annurev.iy.11.040193.001121

P. C. Greig, W. N. Herbert, B. L. Robinette, and L. A. Teot, Amniotic fluid interleukin-10 concentrations increase through pregnancy and are elevated in patients with preterm labor associated with intrauterine infection, American Journal of Obstetrics and Gynecology, vol.173, issue.4, pp.1223-1227, 1995.
DOI : 10.1016/0002-9378(95)91358-0

N. L. Brown, S. A. Alvi, M. G. Elder, P. R. Bennett, and M. H. Sullivan, The regulation of prostaglandin output from term intact fetal membranes byanti-inflammatory cytokines, Immunology, vol.150, issue.1, pp.124-133, 2000.
DOI : 10.1016/1043-4666(90)90018-O

S. J. Fortunato, R. Menon, S. J. Lombardi, and B. Lafleur, Interleukin-10 Inhibition of Gelatinases in Fetal Membranes, Obstetrics & Gynecology, vol.98, issue.2, pp.284-288, 2001.
DOI : 10.1097/00006250-200108000-00018

J. E. Souness, D. Aldous, and C. Sargent, Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors, Immunopharmacology, vol.47, issue.2-3, pp.127-162, 2000.
DOI : 10.1016/S0162-3109(00)00185-5

M. Conti, W. Richter, C. Mehats, G. Livera, J. Y. Park et al., Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling, Journal of Biological Chemistry, vol.278, issue.8, pp.5493-5496, 2003.
DOI : 10.1074/jbc.R200029200

URL : https://hal.archives-ouvertes.fr/inserm-00322006

M. D. Houslay and D. R. Adams, PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization, Biochemical Journal, vol.370, issue.1, pp.1-18, 2003.
DOI : 10.1042/bj20021698

T. Kambayashi, C. O. Jacob, D. Zhou, N. Mazurek, M. Fong et al., Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-and IL-6 release by endotoxin-stimulated macrophages, J. Immunol, vol.155, pp.4909-4916, 1995.

M. W. Verghese, R. T. Mcconnell, A. B. Strickland, R. C. Gooding, S. A. Stimpson et al., Differential regulation of human monocyte-derived TNF-and IL-1-by type IV cAMPphosphodiesterase (cAMP-PDE) inhibitors, J. Pharmacol. Exp. Ther, vol.272, pp.1313-1320, 1995.

W. Timmer, V. Leclerc, G. Birraux, M. Neuhauser, A. Hatzelmann et al., The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of LPS-Stimulated TNF-?? Ex Vivo, The Journal of Clinical Pharmacology, vol.323, issue.25, pp.297-303, 2002.
DOI : 10.1177/00912700222011328

M. Corbel, N. Germain, J. Lanchou, S. Molet, P. M. Silva et al., The Selective Phosphodiesterase 4 Inhibitor RP 73-401 Reduced Matrix Metalloproteinase 9 Activity and Transforming Growth Factor-beta Release During Acute Lung Injury in Mice: The Role of the Balance Between Tumor Necrosis Factor-alpha and Interleukin-10, Journal of Pharmacology and Experimental Therapeutics, vol.301, issue.1, pp.258-265, 2002.
DOI : 10.1124/jpet.301.1.258

T. Kohyama, X. Liu, Y. K. Zhu, F. Q. Wen, H. J. Wang et al., and Neutrophil Elastase, American Journal of Respiratory Cell and Molecular Biology, vol.27, issue.4, pp.487-494, 2002.
DOI : 10.1165/rcmb.4818

C. Mehats, G. Tanguy, B. Paris, B. Robert, N. Pernin et al., Pregnancy induces a modulation of the cAMP phosphodiesterase 4-con- formers ratio in human myometrium: consequences for the utero-relaxant effect of PDE4-selective inhibitors, J. Pharmacol. Exp. Ther, vol.292, pp.817-823, 2000.

S. Oger, C. Mehats, M. S. Barnette, F. Ferre, D. Cabrol et al., Anti-Inflammatory and Utero-Relaxant Effects in Human Myometrium of New Generation Phosphodiesterase 4 Inhibitors, Biology of Reproduction, vol.70, issue.2, pp.458-464, 2004.
DOI : 10.1095/biolreprod.103.023051

URL : https://hal.archives-ouvertes.fr/inserm-00321998

S. J. Fortunato, R. Menon, K. F. Swan, and T. W. Lyden, I. Organ Culture of Amniochorionic Membrane In Vitro, American Journal of Reproductive Immunology, vol.7, issue.3, pp.184-187, 1994.
DOI : 10.1111/j.1600-0897.1994.tb01112.x

R. L. Kincaid and V. C. Manganiello, [43] Assay of cyclic nucleotide phosphodiesterase using radiolabeled and fluorescent substrates, Methods Enzymol, vol.159, pp.457-470, 1988.
DOI : 10.1016/0076-6879(88)59045-6

M. M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976.
DOI : 10.1016/0003-2697(76)90527-3

S. J. Fortunato, R. Menon, and S. J. Lombardi, Interleukin-10 and transforming growth factor-?? inhibit amniochorion tumor necrosis factor-?? production by contrasting mechanisms of action: Therapeutic implications in prematurity, American Journal of Obstetrics and Gynecology, vol.177, issue.4, pp.803-809, 1997.
DOI : 10.1016/S0002-9378(97)70272-2

M. Tsujii and R. N. Dubois, Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2, Cell, vol.83, issue.3, pp.493-501, 1995.
DOI : 10.1016/0092-8674(95)90127-2

F. Vesce, C. Tarabbia, A. Farina, S. Travagli, M. C. Pareschi et al., Modulation of Amnionic Adenylate Cyclase and cAMP Phosphodiesterase by Prostaglandins E<sub>1</sub> and F<sub>2&alpha;</sub>, Gynecologic and Obstetric Investigation, vol.37, issue.2, pp.77-82, 1994.
DOI : 10.1159/000292529

S. L. Jin and M. Conti, Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-?? responses, Proc. Natl. Acad. Sci. USA 99, pp.7628-7633, 2002.
DOI : 10.1016/S0140-6736(99)00442-0

D. J. Dudley, S. S. Edwin, A. Dangerfield, J. Van-waggoner, and M. D. Mitchell, Regulation of Cultured Human Chorion Cell Chemokine Production by Group B Streptococci and Purified Bacterial Products, American Journal of Reproductive Immunology, vol.34, issue.5, pp.264-268, 1996.
DOI : 10.1111/j.1600-0897.1996.tb00175.x

K. Reisenberger, C. Egarter, I. Schiebel, A. Obermair, H. Kiss et al., In vitro cytokine and prostaglandin production by amnion cells in the presence of bacteria, American Journal of Obstetrics and Gynecology, vol.176, issue.5, pp.981-984, 1997.
DOI : 10.1016/S0002-9378(97)70389-2

M. S. Barnette, S. B. Christensen, D. M. Essayan, M. Grous, U. Prabhakar et al., SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions, J. Pharmacol. Exp. Ther, vol.284, pp.420-426, 1998.

C. Jacob, C. Szilagyi, J. M. Allen, C. Bertrand, and V. Lagente, regulation: a cAMP and a PKA-independent mechanism, British Journal of Pharmacology, vol.160, issue.2, pp.257-268, 2004.
DOI : 10.1038/sj.bjp.0705927

P. M. Seldon and M. A. Giembycz, Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10, British Journal of Pharmacology, vol.10, issue.1, pp.58-67, 2001.
DOI : 10.1038/sj.bjp.0704238

D. Rajasingam, P. R. Bennett, S. A. Alvi, M. G. Elder, and M. H. Sullivan, Stimulation of prostaglandin production from intact human fetal membranes by bacteria and bacterial products, Placenta, vol.19, issue.4, pp.301-306, 1998.
DOI : 10.1016/S0143-4004(98)90062-5

R. Romero, M. Emamian, M. Wan, R. Quintero, J. C. Hobbins et al., Prostaglandin concentrations in amniotic fluid of women with intra-amniotic infection and preterm labor, American Journal of Obstetrics and Gynecology, vol.157, issue.6, pp.1461-1467, 1987.
DOI : 10.1016/S0002-9378(87)80245-4

K. Reisenberger, C. Egarter, M. Knofler, I. Schiebel, H. Gregor et al., Cytokine and prostaglandin production by amnion cells in response to the addition of different bacteria, American Journal of Obstetrics and Gynecology, vol.178, issue.1, pp.50-53, 1998.
DOI : 10.1016/S0002-9378(98)70625-8

T. A. Sato, J. A. Keelan, and M. D. Mitchell, Critical Paracrine Interactions Between TNF-?? and IL-10 Regulate Lipopolysaccharide-Stimulated Human Choriodecidual Cytokine and Prostaglandin E2 Production, The Journal of Immunology, vol.170, issue.1, pp.158-166, 2003.
DOI : 10.4049/jimmunol.170.1.158

J. L. Jimenez, M. A. Iniguez, M. A. Munoz-fernandez, and M. Fresno, Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes, Cellular Signalling, vol.16, issue.12, pp.1363-1373, 2004.
DOI : 10.1016/j.cellsig.2004.04.002

C. J. Lo, M. Fu, F. R. Lo, and H. G. Cryer, CYCLOOXYGENASE 2 (COX-2) GENE ACTIVATION IS REGULATED BY CYCLIC ADENOSINE MONOPHOSPHATE, Shock, vol.13, issue.1, pp.41-45, 2000.
DOI : 10.1097/00024382-200013010-00008

K. Schroer, Y. Zhu, M. A. Saunders, W. G. Deng, X. M. Xu et al., Obligatory Role of Cyclic Adenosine Monophosphate Response Element in Cyclooxygenase-2 Promoter Induction and Feedback Regulation by Inflammatory Mediators, Circulation, vol.105, issue.23, pp.2760-2765, 2002.
DOI : 10.1161/01.CIR.0000018127.10968.34

P. J. Barnes, Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms, Clinical Science, vol.94, issue.6, pp.557-572, 1998.
DOI : 10.1042/cs0940557

W. C. Lai, M. Zhou, U. Shankavaram, G. Peng, and L. M. Wahl, Differential Regulation of Lipopolysaccharide-Induced Monocyte Matrix Metalloproteinase (MMP)-1 and MMP-9 by p38 and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinases, The Journal of Immunology, vol.170, issue.12, pp.6244-6249, 2003.
DOI : 10.4049/jimmunol.170.12.6244

Y. Zhang, D. L. Dewitt, T. B. Mcneely, S. M. Wahl, and L. M. Wahl, Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases., Journal of Clinical Investigation, vol.99, issue.5, pp.894-900, 1997.
DOI : 10.1172/JCI119254

P. M. Mertz, D. L. Dewitt, W. G. Stetler-stevenson, and L. M. Wahl, Interleukin 10 suppression of monocyte prostaglandin H synthase-2: mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production, J. Biol. Chem, vol.269, pp.21322-21329, 1994.

J. Mclaren, D. J. Taylor, and S. C. Bell, Prostaglandin E2-dependent production of latent matrix metalloproteinase-9 in cultures of human fetal membranes, Molecular Human Reproduction, vol.6, issue.11, pp.1033-1040, 2000.
DOI : 10.1093/molehr/6.11.1033

L. J. Mccawley, S. Li, M. Benavidez, J. Halbleib, E. V. Wattenberg et al., Elevation of intracellular cAMP inhibits growth factormediated matrix metalloproteinase-9 induction and keratinocyte migration, Mol. Pharmacol, vol.58, pp.145-151, 2000.

S. Cole, R. Smith, and W. Giles, Tocolysis: current controversies, future directions, Curr. Opin. Investig. Drugs, vol.5, pp.424-429, 2004.

J. A. Loudon, K. M. Groom, and P. R. Bennett, Prostaglandin inhibitors in preterm labour, Best Practice & Research Clinical Obstetrics & Gynaecology, vol.17, issue.5, pp.731-744, 2003.
DOI : 10.1016/S1521-6934(03)00047-6

D. Spina, Phosphodiesterase-4 Inhibitors in the Treatment of Inflammatory Lung Disease, Drugs, vol.161, issue.23, pp.2575-2594, 2003.
DOI : 10.2165/00003495-200363230-00002

M. J. Leroy, I. Cedrin, M. Breuiller, Y. Giovagrandi, and F. Ferre, Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term, Biochemical Pharmacology, vol.38, issue.1, pp.9-15, 1989.
DOI : 10.1016/0006-2952(89)90142-1