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Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain.

Abstract : It has been reported that cocaine and amphetamine-regulated transcript (Cart) peptides can increase locomotor activity and produce a conditioned place preference. To establish whether or not Cart can be consider as a valuable marker of addiction we performed a comparative study of the expression of Cart and Fos genes by several drugs of abuse. This was achieved using real-time quantitative polymerase chain reaction in four rat brain structures: prefrontal cortex, caudate putamen, nucleus accumbens and hippocampus. As expected, a significant induction of the immediate early gene Fos was observed after acute administration of morphine, cocaine, 3, 4-methylenedioxymethamphetamine and Delta(9)-Tetrahydrocannabinol. On the contrary none of these drugs was able to produce a significant change in Cart mRNA levels demonstrating that the expression of this gene is not modulated by drugs of abuse in these brain structures.
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https://www.hal.inserm.fr/inserm-00171266
Contributor : Cynthia Marie-Claire <>
Submitted on : Thursday, September 13, 2007 - 9:13:10 AM
Last modification on : Tuesday, September 22, 2020 - 3:58:46 AM
Long-term archiving on: : Friday, April 9, 2010 - 1:56:12 AM

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  • HAL Id : inserm-00171266, version 1
  • PUBMED : 12821175

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Cynthia Marie-Claire, Ingrid Laurendeau, Corine Canestrelli, Cindie Courtin, Michel Vidaud, et al.. Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain.. Neuroscience Letters, Elsevier, 2003, 345 (2), pp.77-80. ⟨inserm-00171266⟩

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