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Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?

Abstract : Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.
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https://www.hal.inserm.fr/inserm-00170686
Contributor : Celine Mehats <>
Submitted on : Monday, September 10, 2007 - 1:36:28 PM
Last modification on : Tuesday, September 22, 2020 - 3:38:20 AM
Long-term archiving on: : Friday, November 25, 2016 - 6:26:54 PM

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Céline Méhats, Thomas Schmitz, Michelle Breuiller-Fouché, Marie-Josèphe Leroy, Dominique Cabrol. Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?. American Journal of Obstetrics and Gynecology, Elsevier, 2006, 195 (1), pp.184-5. ⟨10.1016/j.ajog.2005.12.006⟩. ⟨inserm-00170686⟩

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