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Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries.: Tuberculosis on antiretroviral therapy

Abstract : We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.
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https://www.hal.inserm.fr/inserm-00170433
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Submitted on : Friday, May 23, 2014 - 10:19:17 AM
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Martin Brinkhof, Matthias Egger, Andrew Boulle, Margaret May, Mina Hosseinipour, et al.. Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries.: Tuberculosis on antiretroviral therapy. Clinical Infectious Diseases, Oxford University Press (OUP), 2007, 45 (11), pp.1518-21. ⟨10.1086/522986⟩. ⟨inserm-00170433⟩

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