Skip to Main content Skip to Navigation
Journal articles

Physico-chemical-mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates.

Abstract : Calcium phosphate cements (CPCs) are successfully used as bone substitutes in dentistry and orthopaedic applications. This study investigated the physico-chemical-mechanical properties of and in vitro biological properties (cell response) of CPCs prepared with amorphous calcium carbonate phosphate (ACCP) doped with magnesium (ACCP-Mg), zinc (ACCp-Zn) or fluoride (ACCP-F) ions. The experimental CPC consisted of alpha-TCP, doped ACCP, and MPCM powders as matrix and biphasic calcium phosphate (BCP) granules. X-ray diffraction analysis showed that the matrix converted to apatite with poor crystallinity (reflecting small crystal size) after setting for 24 h, while BCP remained apparently unchanged. Cements with ACCP-F (F-CPC) had shorter setting times and greater compressive strength compared to cements with ACCP-Mg (Mg-CPC) or ACCP-Zn (Zn-CPC). Scanning electron microscopy (SEM) showed that crystals set on Mg-CPC and Zn-CPC were smaller compared to those on F-CPC. The total porosity of Mg-CPC was greater compared to Zn-CPC or F-CPC. Osteoblast-like cells, MC3T3-E1, remained viable and maintained their ability to express alkaline phosphatase in contact with the CPCs with doped ACCPs.
Document type :
Journal articles
Complete list of metadatas

Cited literature [13 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00170245
Contributor : Pierre Weiss <>
Submitted on : Friday, September 7, 2007 - 4:26:47 PM
Last modification on : Wednesday, August 14, 2019 - 10:47:04 AM
Long-term archiving on: : Friday, April 9, 2010 - 1:41:39 AM

Identifiers

Collections

Citation

Marion Julien, Ibrahim Khairoun, Racquel Legeros, Séverine Delplace, Paul Pilet, et al.. Physico-chemical-mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates.. Biomaterials, Elsevier, 2007, 28 (6), pp.956-65. ⟨10.1016/j.biomaterials.2006.10.018⟩. ⟨inserm-00170245⟩

Share

Metrics

Record views

473

Files downloads

3485