A multiple imputation method for missing covariates in non-linear mixed-effects models with application to HIV dynamics, Statistics in Medicine, vol.46, issue.12, pp.1755-1769, 2001. ,
DOI : 10.1002/sim.816
Analysis of left-censored longitudinal data with application to viral load in HIV infection, Biostatistics, vol.1, issue.4, pp.355-368, 2000. ,
DOI : 10.1093/biostatistics/1.4.355
Identification of significant host factors for HIV dynamics modelled by non-linear mixed-effects models, Statistics in Medicine, vol.181, issue.5, pp.753-771, 2002. ,
DOI : 10.1002/sim.1015
A 15-Year Follow-up Study of Ventilatory Function in Adults with Asthma, New England Journal of Medicine, vol.339, issue.17, pp.1194-200, 1998. ,
DOI : 10.1056/NEJM199810223391703
Pharmacokinetics and Potential Interactions Amongst Antiretroviral Agents Used To Treat Patients with HIV Infection, Clinical Pharmacokinetics, vol.36, issue.4, pp.289-304, 1999. ,
DOI : 10.2165/00003088-199936040-00004
Estimating population kinetics, Critical Reviews in Biomedical Engineering, vol.8, pp.195-222, 1982. ,
Nonlinear Mixed Effects Models for Repeated Measures Data, Biometrics, vol.46, issue.3, pp.673-687, 1990. ,
DOI : 10.2307/2532087
Mixed-effect models in S and Splus, 2000. ,
A note on the use of Laplace's approximation for nonlinear mixed-effects models, Biometrika, vol.83, issue.2, pp.447-452, 1996. ,
DOI : 10.1093/biomet/83.2.447
Assessing antiviral potency of anti-HIV therapies in vivo by comparing viral decay rates in viral dynamic models, Biostatistics, vol.2, issue.1, pp.13-29, 2001. ,
DOI : 10.1093/biostatistics/2.1.13
Assessment of actual significance levels for covariate effects in NONMEM, Journal of Pharmacokinetics and Pharmacodynamics, vol.28, issue.3, pp.231-252, 2001. ,
DOI : 10.1023/A:1011527125570
EVALUATION OF TESTS BASED ON INDIVIDUAL VERSUS POPULATION MODELING TO COMPARE DISSOLUTION CURVES, Journal of Biopharmaceutical Statistics, vol.11, issue.3, pp.107-123, 2001. ,
DOI : 10.1081/BIP-100107652
Evaluation by simulation of tests based on non-linear mixed-effects models in pharmacokinetic interaction and bioequivalence cross-over trials, Statistics in Medicine, vol.83, issue.10, pp.1509-1524, 2005. ,
DOI : 10.1002/sim.2047
Approximations to the log-likelihood function in the nonlinear mixed-effect models, Journal of Computational and Graphical Statistics, vol.4, pp.12-35, 1995. ,
Laplace's approximation for nonlinear mixed models, Biometrika, vol.80, issue.4, pp.791-795, 1993. ,
DOI : 10.1093/biomet/80.4.791
An approximate likelihood approach to nonlinear mixed effects models via spline approximation, Computational Statistics & Data Analysis, vol.46, issue.4, pp.747-776, 2004. ,
DOI : 10.1016/j.csda.2003.10.011
Maximum likelihood from incomplete data via the EM algorithm, Journal of the Royal Statistical Society: Series B, vol.39, pp.1-38, 1977. ,
Calculating the content and boundary of the highest posterior density region via data augmentation, Biometrika, vol.77, issue.3, pp.649-652, 1990. ,
DOI : 10.1093/biomet/77.3.649
An EM Algorithm for Nonlinear Random Effects Models, Biometrics, vol.52, issue.3, pp.934-944, 1996. ,
DOI : 10.2307/2533054
A Joint Model for Nonlinear Mixed-Effects Models With Censoring and Covariates Measured With Error, With Application to AIDS Studies, Journal of the American Statistical Association, vol.97, issue.460, pp.955-964, 2002. ,
DOI : 10.1198/016214502388618744
Exact and Approximate Inferences for Nonlinear Mixed-Effects Models With Missing Covariates, Journal of the American Statistical Association, vol.99, issue.467, pp.700-709, 2004. ,
DOI : 10.1198/016214504000001006
Convergence of a stochastic approximation version of the EM algorithm, Annals of Statistics, vol.27, pp.94-128, 1999. ,
Maximum likelihood estimation in nonlinear mixed effects models, Computational Statistics & Data Analysis, vol.49, issue.4, pp.1020-1038, 2005. ,
DOI : 10.1016/j.csda.2004.07.002
Coupling a stochastic approximation version of EM with an MCMC procedure, ESAIM: Probability and Statistics, vol.8, pp.115-131, 2005. ,
DOI : 10.1051/ps:2004007
Finding the observed information matrix when using the EM algorithm, Journal of the Royal Statistical Society: Series B, vol.44, pp.226-233, 1982. ,
A sample size computation method for ,