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Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines.

Abstract : Novel 1,4-benzodiazepine compounds were synthesized and evaluated for their ability to inhibit the proliferation of tumor cells. Some compounds revealed activities in the micromolar range and were more efficient than reference compound Ro 5-4864. Preliminary SAR helped to identify critical motifs for antiproliferative activity and led to the discovery of a compound selective for a melanoma cell line, known for its resistance to chemotherapy.
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https://www.hal.inserm.fr/inserm-00168656
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Submitted on : Thursday, August 30, 2007 - 3:31:46 PM
Last modification on : Saturday, June 25, 2022 - 8:47:19 PM
Long-term archiving on: : Friday, April 9, 2010 - 1:18:51 AM

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Jennifer Dourlat, Wang-Qing Liu, Nohad Gresh, Christiane Garbay. Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (9), pp.2527-30. ⟨10.1016/j.bmcl.2007.02.016⟩. ⟨inserm-00168656⟩

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