Skip to Main content Skip to Navigation
Journal articles

Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.: hCG signaling is impaired in trisomy 21 pregnancy

Abstract : Placental development is markedly abnormal in women bearing a fetus with trisomy 21, with defective syncytiotrophoblast (ST) formation and function. The ST occurs from cytotrophoblast (CT) fusion and plays an essential role by secreting human chorionic gonadotropin (hCG), which is essential to placental development. In trisomy of chromosome 21 (T21) pregnancies, CTs do not fuse and differentiate properly into STs, leading to the secretion of an abnormal and weakly bioactive hCG. In this study we report for the first time, a marked decrease in the number of mature hCG receptor (LH/CG-R) molecules expressed at the surface of T21-affected CTs. The LH/CG-R seems to be functional based on sequencing that revealed no mutations or deletions and binding of recombinant hCG as well as endogenous hCG. We hypothesize that weakly bioactive hCG and lower LH/CG-R expression may be involved in the defect of ST formation. Interestingly, the defective ST formation is mimicked in normal CT cultures by using LH/CG-R small interfering RNA, which result in a lower hCG secretion. Furthermore, treatment of T21-affected CTs with recombinant hCG overcomes in vitro the T21 phenotype, allowing CTs to fuse and form a large ST. These results illustrate for the first time in trisomy 21 pathology, how abnormal endogenous hCG signaling impairs human placental development.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00168635
Contributor : Jean-Louis Frendo <>
Submitted on : Wednesday, August 29, 2007 - 2:44:13 PM
Last modification on : Tuesday, September 22, 2020 - 3:58:38 AM
Long-term archiving on: : Friday, April 9, 2010 - 1:18:08 AM

Identifiers

Collections

Citation

Guillaume Pidoux, Pascale Gerbaud, Olivier Marpeau, Jean Guibourdenche, Fatima Ferreira, et al.. Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.: hCG signaling is impaired in trisomy 21 pregnancy. Endocrinology, Endocrine Society, 2007, 148 (11), pp.5403-13. ⟨10.1210/en.2007-0589⟩. ⟨inserm-00168635⟩

Share

Metrics

Record views

746

Files downloads

1359