Skip to Main content Skip to Navigation
Journal articles

Exploring the pharmacological properties of insect nicotinic acetylcholine receptors.

Abstract : Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology.
Document type :
Journal articles
Complete list of metadatas

Cited literature [51 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00168267
Contributor : Christian Hamel <>
Submitted on : Monday, August 27, 2007 - 8:32:31 AM
Last modification on : Thursday, September 10, 2020 - 3:08:09 PM
Long-term archiving on: : Friday, November 25, 2016 - 5:28:17 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Steeve Thany, Guy Lenaers, Valérie Raymond-Delpech, David Sattelle, Bruno Lapied. Exploring the pharmacological properties of insect nicotinic acetylcholine receptors.. Trends in Pharmacological Sciences, Elsevier, 2007, 28 (1), pp.14-22. ⟨10.1016/j.tips.2006.11.006⟩. ⟨inserm-00168267⟩

Share

Metrics

Record views

386