J. Adams, Ways of dying: multiple pathways to apoptosis, Genes & Development, vol.17, issue.20, pp.2481-2495, 2003.
DOI : 10.1101/gad.1126903

M. Akiyoshoi, S. Yano, H. Nakada, K. Sato, and T. Shoji, Study on damage of the vestibular organs due to aminoglycoside antibiotics by means of supravital reduction of nitro-BT, Ear Res Jpn, vol.7, pp.98-100, 1976.

J. Aran, Current perspectives on inner ear toxicity???, ??????, ???, Otolaryngology - Head and Neck Surgery, vol.112, issue.1, pp.133-144, 1995.
DOI : 10.1016/S0194-5998(95)70313-6

D. Bagger-sjoback and J. Wersall, Gentamicin-Induced Mitochondrial Damage in Inner Ear Sensory Cells of the Lizard Calotes Versicolor, Acta Oto-Laryngologica, vol.54, issue.1-6, pp.35-51, 1978.
DOI : 10.3109/00016487809124718

R. Baird, M. Torres, and N. Schuff, Hair cell regeneration in the bullfrog vestibular otolith organs following aminoglycoside toxicity, Hearing Research, vol.65, issue.1-2, pp.164-174, 1993.
DOI : 10.1016/0378-5955(93)90211-I

R. Baird, M. Burton, D. Fashena, and R. Naeger, Hair cell recovery in mitotically blocked cultures of the bullfrog saccule, Proceedings of the National Academy of Sciences, vol.15, issue.4, pp.11722-11729, 2000.
DOI : 7722642

A. Battaglia, K. Pak, D. Brors, D. Bodmer, J. Frangos et al., Involvement of ras activation in toxic hair cell damage of the mammalian cochlea, Neuroscience, vol.122, issue.4, pp.1025-1035, 2003.
DOI : 10.1016/j.neuroscience.2003.08.041

P. Bernardi, K. Broekemeier, and D. Pfeiffer, Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane, Journal of Bioenergetics and Biomembranes, vol.1183, issue.5, pp.509-517, 1994.
DOI : 10.1007/BF00762735

S. Bhave, E. Oesterle, and M. Coltrera, Macrophage and microglia-like cells in the avian inner ear, The Journal of Comparative Neurology, vol.17, issue.2, pp.241-256, 1998.
DOI : 10.1002/(SICI)1096-9861(19980824)398:2<241::AID-CNE6>3.0.CO;2-0

H. Chen and D. Chan, Emerging functions of mammalian mitochondrial fusion and fission, Human Molecular Genetics, vol.14, issue.suppl_2, pp.283-289, 2005.
DOI : 10.1093/hmg/ddi270

A. Cheng, L. Cunningham, and E. Rubel, Hair Cell Death in the Avian Basilar Papilla: Characterization of the in vitro Model and Caspase Activation, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.1, pp.91-105, 2003.
DOI : 10.1007/s10162-002-3016-8

S. Coombs and J. Montgomery, The Enigmatic Lateral Line System, Comparative hearing. Fish and amphibians, 1999.
DOI : 10.1007/978-1-4612-0533-3_8

D. Cotanche, K. Lee, J. Stone, and D. Picard, Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage, Anatomy and Embryology, vol.189, issue.1, pp.1-18, 1994.
DOI : 10.1007/BF00193125

L. Cunningham, A. Cheng, and E. Rubel, Caspase activation in hair cells of the mouse utricle exposed to neomycin, J Neurosci, vol.22, pp.8532-8540, 2002.

L. Cunningham, J. Matsui, M. Warchol, and E. Rubel, Overexpression ofBcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utriclein vitro, Journal of Neurobiology, vol.96, issue.1, pp.89-100, 2004.
DOI : 10.1002/neu.20006

C. Dai, D. Mangiardi, D. Cotanche, and P. Steyger, Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo, Hearing Research, vol.213, issue.1-2, pp.64-78, 2006.
DOI : 10.1016/j.heares.2005.11.011

C. Dambly-chaudiere, D. Sapede, F. Soubiran, K. Decorde, N. Gompel et al., The lateral line of zebrafish: a model system for the analysis of morphogenesis and neural development in vertebrates, Biology of the Cell, vol.95, issue.9, pp.579-587, 2003.
DOI : 10.1016/j.biolcel.2003.10.005

URL : https://hal.archives-ouvertes.fr/hal-00260384

N. Danial and S. Korsmeyer, Cell Death, Cell, vol.116, issue.2, pp.205-219, 2004.
DOI : 10.1016/S0092-8674(04)00046-7

J. Darrouzet and A. Guilhaume, [Ototoxicity of kanamycin studied day by day. Experimental electron microscopic study], Rev Laryngol Otol Rhinol (Bord), vol.95, pp.601-621, 1974.

J. Davies, L. Gorini, and B. Davis, Misreading of RNA codewords induced by aminoglycoside antibiotics, Mol Pharmacol, vol.1, pp.93-106, 1965.

N. Dehne, J. Lautermann, W. Cate, U. Rauen, and H. De-groot, In vitro effects of hydrogen peroxide on the cochlear neurosensory epithelium of the guinea pig, Hearing Research, vol.143, issue.1-2, pp.162-170, 2000.
DOI : 10.1016/S0378-5955(00)00036-8

N. Dehne, U. Rauen, H. De-groot, and J. Lautermann, Involvement of the mitochondrial permeability transition in gentamicin ototoxicity, Hearing Research, vol.169, issue.1-2, pp.47-55, 2002.
DOI : 10.1016/S0378-5955(02)00338-6

S. Desagher and J. Martinou, Mitochondria as the central control point of apoptosis, Trends in Cell Biology, vol.10, issue.9, pp.369-377, 2000.
DOI : 10.1016/S0962-8924(00)01803-1

D. Ding, S. Mcfadden, R. Browne, and R. Salvi, Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells, Hearing Research, vol.185, issue.1-2, pp.90-96, 2003.
DOI : 10.1016/S0378-5955(03)00258-2

S. Dijkgraaf, THE FUNCTIONING and SIGNIFICANCE OF THE LATERAL-LINE ORGANS, Biological Reviews, vol.255, issue.3, pp.51-105, 1963.
DOI : 10.1038/194600b0

L. Duckert and E. Rubel, Ultrastructural observations on regenerating hair cells in the chick basilar papilla, Hearing Research, vol.48, issue.1-2, pp.161-182, 1990.
DOI : 10.1016/0378-5955(90)90206-5

A. Duvall and J. Wersall, Site of Action of Streptomycin Upon Inner Ear Sensory Cells, Acta Oto-Laryngologica, vol.54, issue.3-6, pp.581-598, 1964.
DOI : 10.3109/00016486409137120

C. Fermin and M. Igarashi, Aminoglycoside ototoxicity in the chick (Gallus domesticus) inner ear, American Journal of Otolaryngology, vol.4, issue.3, pp.174-183, 1983.
DOI : 10.1016/S0196-0709(83)80040-4

J. Fernandez-checa, Redox regulation and signaling lipids in mitochondrial apoptosis, Biochemical and Biophysical Research Communications, vol.304, issue.3, pp.471-479, 2003.
DOI : 10.1016/S0006-291X(03)00619-3

N. Fischel-ghodsian, Genetic Factors in Aminoglycoside Toxicity, Annals of the New York Academy of Sciences, vol.141, issue.1, pp.99-109, 1999.
DOI : 10.1111/j.1749-6632.1999.tb08639.x

A. Flock, B. Flock, A. Fridberger, and W. Jager, Methods for integrating fluorimetry in the study of hearing organ structure and function, Hearing Research, vol.106, issue.1-2, pp.29-38, 1997.
DOI : 10.1016/S0378-5955(96)00215-8

A. Forge, Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment, Hearing Research, vol.19, issue.2, pp.171-182, 1985.
DOI : 10.1016/0378-5955(85)90121-2

A. Forge and L. Li, Apoptotic death of hair cells in mammalian vestibular sensory epithelia, Hearing Research, vol.139, issue.1-2, pp.97-115, 2000.
DOI : 10.1016/S0378-5955(99)00177-X

A. Forge and G. Richardson, Freeze fracture analysis of apical membranes in cochlear cultures: differences between basal and apicalcoil outer hair cells and effects of neomycin, Journal of Neurocytology, vol.23, issue.10, pp.854-867, 1993.
DOI : 10.1007/BF01186357

A. Forge and J. Schacht, Aminoglycoside Antibiotics, Audiology and Neuro-Otology, vol.5, issue.1, pp.3-22, 2000.
DOI : 10.1159/000013861

L. Fredelius and H. Rask-andersen, The role of macrophages in the disposal of degeneration products within the organ of corti after acoustic overstimulation, Acta Oto-Laryngologica, vol.29, issue.1-2, pp.76-82, 1990.
DOI : 10.1084/jem.123.1.145

D. Furness and C. Hackney, Morphological changes to the stereociliary bundles in the guinea pig cochlea after kanamycin treatment, British Journal of Audiology, vol.70, issue.4, pp.253-259, 1986.
DOI : 10.3109/00016487409129729

J. Gale, J. Meyers, A. Periasamy, and J. Corwin, Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule, Journal of Neurobiology, vol.19, issue.2, pp.81-92, 2002.
DOI : 10.1002/neu.10002

M. Guan, N. Fischel-ghodsian, and G. Attardi, A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity, Human Molecular Genetics, vol.9, issue.12, pp.1787-1793, 2000.
DOI : 10.1093/hmg/9.12.1787

R. Gutell, Collection of small subunit (16S- and 16S-like) ribosomal RNA structures: 1994, Nucleic Acids Research, vol.22, issue.17, pp.3502-3507, 1994.
DOI : 10.1093/nar/22.17.3502

J. Harris, A. Cheng, L. Cunningham, G. Macdonald, D. Raible et al., Neomycin-Induced Hair Cell Death and Rapid Regeneration in the Lateral Line of Zebrafish ( Danio rerio ), JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.2, pp.219-234, 2003.
DOI : 10.1007/s10162-002-3022-x

E. Hashino, S. Marlene, and R. Salvi, Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells, Brain Research, vol.777, issue.1-2, pp.75-85, 1997.
DOI : 10.1016/S0006-8993(97)00977-3

J. Hawkins, . Jr, and M. Lurie, XCVI The Ototoxicity of Dihydrostreptomycin and Neomycin in the Cat, Annals of Otology, Rhinology & Laryngology, vol.33, issue.4, pp.1128-1148, 1953.
DOI : 10.1177/000348945306200415

D. Henderson, S. Mcfadden, C. Liu, N. Hight, and X. Zheng, The Role of Antioxidants in Protection from Impulse Noise, Annals of the New York Academy of Sciences, vol.111, issue.8, pp.368-380, 1999.
DOI : 10.1111/j.1749-6632.1999.tb08655.x

D. Hentschel, K. Park, L. Cilenti, A. Zervos, I. Drummond et al., Acute renal failure in zebrafish: a novel system to study a complex disease, AJP: Renal Physiology, vol.288, issue.5, pp.923-929, 2005.
DOI : 10.1152/ajprenal.00386.2004

P. Hernandez, V. Moreno, F. Olivari, and M. Allende, Sub-lethal concentrations of waterborne copper are toxic to lateral line neuromasts in zebrafish (Danio rerio), Hearing Research, vol.213, issue.1-2, pp.1-10, 2006.
DOI : 10.1016/j.heares.2005.10.015

J. Heydt, L. Cunningham, E. Rubel, and M. Coltrera, Round window gentamicin application: an inner ear hair cell damage protocol for the mouse, Hearing Research, vol.192, issue.1-2, pp.65-74, 2004.
DOI : 10.1016/j.heares.2004.01.006

H. Hiel, J. Erre, C. Aurousseau, R. Bouali, D. Dulon et al., Gentamicin Uptake by Cochlear Hair Cells Precedes Hearing Impairment during Chronic Treatment, International Journal of Audiology, vol.37, issue.1, pp.78-87, 1993.
DOI : 10.3109/00016488909125546

H. Hinshaw and W. Feldman, Streptomycin in the treatment of clinical tuberculosis: a preliminary report, Proc Mayo Clinic, vol.20, pp.313-318, 1945.

K. Hirose, D. Hockenbery, and E. Rubel, Reactive oxygen species in chick hair cells after gentamicin exposure in vitro, Hearing Research, vol.104, issue.1-2, pp.1-14, 1997.
DOI : 10.1016/S0378-5955(96)00169-4

K. Hirose, L. Westrum, J. Stone, L. Zirpel, and E. Rubel, Dynamic Studies of Ototoxicity in Mature Avian Auditory Epithelium, Annals of the New York Academy of Sciences, vol.416, issue.2, pp.389-409, 1999.
DOI : 10.1111/j.1749-6632.1999.tb08657.x

K. Hirose, L. Westrum, D. Cunningham, and E. Rubel, Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure, The Journal of Comparative Neurology, vol.19, issue.2, pp.164-180, 2004.
DOI : 10.1002/cne.11046

G. Hyde and E. Rubel, Mitochondrial role in hair cell survival after injury, Otolaryngology - Head and Neck Surgery, vol.113, issue.5, pp.530-540, 1995.
DOI : 10.1016/S0194-5998(95)70043-9

S. Imamura and J. Adams, Distribution of Gentamicin in the Guinea Pig Inner Ear after Local or Systemic Application, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.2, pp.176-195, 2003.
DOI : 10.1007/s10162-002-2036-8

J. Janas, D. Cotanche, and E. Rubel, Avian cochlear hair cell regeneration: stereological analyses of damage and recovery from a single high dose of gentamicin, Hearing Research, vol.92, issue.1-2, pp.17-29, 1995.
DOI : 10.1016/0378-5955(95)00190-5

H. Jiang, S. Sha, A. Forge, and J. Schacht, Caspase-independent pathways of hair cell death induced by kanamycin in vivo, Cell Death and Differentiation, vol.95, issue.1, pp.20-30, 2006.
DOI : 10.1046/j.1471-4159.2002.00935.x

J. Jones and J. Corwin, Regeneration of sensory cells after laser ablation in the lateral line system: hair cell lineage and macrophage behavior revealed by time-lapse video microscopy, J Neurosci, vol.16, pp.649-662, 1996.

J. Jorgensen and A. Flock, The ultrastructure of lateral line sense organs in the adult salamanderAmbystoma mexicanum, Journal of Neurocytology, vol.178, issue.2, pp.133-142, 1973.
DOI : 10.1007/BF01474715

M. Kaul, C. Barbieri, and D. Pilch, Defining the Basis for the Specificity of Aminoglycoside-rRNA Recognition: A Comparative Study of Drug Binding to the A Sites of Escherichia coli and Human rRNA, Journal of Molecular Biology, vol.346, issue.1, pp.119-134, 2005.
DOI : 10.1016/j.jmb.2004.11.041

S. Kaus, The Effect of Aminoglycoside Antibiotics on the Lateral Line Organ of Aplocheilus lineatus (Cyprinodontidae), Acta Oto-Laryngologica, vol.103, issue.3, pp.291-298, 1987.
DOI : 10.3109/00016488709107285

M. Kelley, D. Talreja, and J. Corwin, Replacement of hair cells after laser microbeam irradiation in cultured organs of Corti from embryonic and neonatal mice, J Neurosci, vol.15, pp.3013-3026, 1995.

T. Kita, T. Nakagawa, T. Kim, K. Iwai, S. Takebayashi et al., Serofendic acid promotes survival of auditory hair cells and neurons of mice, NeuroReport, vol.16, issue.7, pp.689-692, 2005.
DOI : 10.1097/00001756-200505120-00007

R. Kopke, K. Allen, D. Henderson, M. Hoffer, D. Frenz et al., A Radical Demise: Toxins and Trauma Share Common Pathways in Hair Cell Death, Annals of the New York Academy of Sciences, vol.109, issue.Suppl. 3, pp.171-191, 1999.
DOI : 10.1111/j.1749-6632.1999.tb08641.x

M. Kossl, G. Richardson, and I. Russell, Stereocilia bundle stiffness: Effects of neomycin sulphate, A23187 and Concanavalin A, Hearing Research, vol.44, issue.2-3, pp.217-229, 1990.
DOI : 10.1016/0378-5955(90)90082-Z

G. Kroemer and J. Reed, Mitochondrial control of cell death, Nature Medicine, vol.6, issue.5, pp.513-519, 2000.
DOI : 10.1038/74994

K. Lee and R. Kimura, Ultrastructural changes of the vestibular sensory organs after streptomycin application on the lateral canal, Scan Microsc, vol.8, pp.107-121, 1994.

J. Lee, T. Nakagawa, T. Kim, F. Iguchi, T. Endo et al., Signaling pathway for apoptosis of vestibular hair cells of Mice due to aminoglycosides, Acta Oto-Laryngologica, vol.26, issue.sup551, pp.69-74, 2004.
DOI : 10.1016/S0378-5955(02)00634-2

M. Lenoir and J. Puel, Dose-dependent changes in the rat cochlea following aminoglycoside intoxidation. II. Histological study, Hearing Research, vol.26, issue.2, pp.199-209, 1987.
DOI : 10.1016/0378-5955(87)90112-2

M. Lenoir, N. Daudet, G. Humbert, R. N. Gallego, M. Pujol et al., Morphological and molecular changes in the inner hair cell region of the rat cochlea after amikacin treatment, Journal of Neurocytology, vol.28, issue.10/11, pp.925-937, 1999.
DOI : 10.1023/A:1007034508547

E. Leonova and Y. Raphael, Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti, Hearing Research, vol.113, issue.1-2, pp.14-28, 1997.
DOI : 10.1016/S0378-5955(97)00130-5

F. Leydig, Ueber die Schleimkanale der Knochenfische, Mull Arch Anat Physiol, pp.170-181, 1850.

I. Lopez, V. Honrubia, S. Lee, G. Schoeman, and K. Beykirch, Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment, International Journal of Developmental Neuroscience, vol.15, issue.4-5, pp.447-461, 1997.
DOI : 10.1016/S0736-5748(96)00103-7

D. Mangiardi, K. Mclaughlin-williamson, K. May, E. Messana, D. Mountain et al., Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatment, The Journal of Comparative Neurology, vol.163, issue.1, pp.1-18, 2004.
DOI : 10.1002/cne.20129

M. Mather and H. Rottenberg, Polycations induce the release of soluble intermembrane mitochondrial proteins, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1503, issue.3, pp.357-368, 2001.
DOI : 10.1016/S0005-2728(00)00231-0

J. Matsui and D. Cotanche, Sensory hair cell death and regeneration: two halves of the same equation, Current Opinion in Otolaryngology & Head and Neck Surgery, vol.12, issue.5, pp.418-425, 2004.
DOI : 10.1097/01.moo.0000136873.56878.56

J. Matsui, E. Oesterle, J. Stone, and E. Rubel, Characterization of Damage and Regeneration in Cultured Avian Utricles, Journal of the Association for Research in Otolaryngology, vol.1, issue.1, pp.46-63, 2000.
DOI : 10.1007/s101620010005

J. Matsui, J. Ogilvie, and M. Warchol, Inhibition of caspases prevents ototoxic and ongoing hair cell death, J Neurosci, vol.22, pp.1218-1227, 2002.

J. Matsui, A. Haque, D. Huss, E. Messana, J. Alosi et al., Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo, J Neurosci, vol.23, pp.6111-6122, 2003.

J. Matsui, J. Gale, and M. Warchol, Critical signaling events during the aminoglycoside-induced death of sensory hair cellsin vitro, Journal of Neurobiology, vol.274, issue.2, pp.250-266, 2004.
DOI : 10.1002/neu.20054

B. Mcdowell, S. Davies, and A. Forge, The effect of gentamicin-induced hair cell loss on the tight junctions of the reticular lamina, Hearing Research, vol.40, issue.3, pp.221-232, 1989.
DOI : 10.1016/0378-5955(89)90163-9

S. Mcfadden, D. Ding, D. Salvemini, and R. Salvi, M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity, Toxicology and Applied Pharmacology, vol.186, issue.1, pp.46-54, 2003.
DOI : 10.1016/S0041-008X(02)00017-0

W. Metcalfe, C. Kimmel, and E. Schabtach, Anatomy of the posterior lateral line system in young larvae of the zebrafish, The Journal of Comparative Neurology, vol.219, issue.3, pp.377-389, 1985.
DOI : 10.1002/cne.902330307

T. Minamikawa, D. Williams, D. Bowser, and P. Nagley, Mitochondrial Permeability Transition and Swelling Can Occur Reversibly without Inducing Cell Death in Intact Human Cells, Experimental Cell Research, vol.246, issue.1, pp.26-37, 1999.
DOI : 10.1006/excr.1998.4290

S. Murakami, L. Cunningham, L. Werner, E. Bauer, R. Pujol et al., Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio), Hearing Research, vol.186, issue.1-2, pp.47-56, 2003.
DOI : 10.1016/S0378-5955(03)00259-4

S. Myrdal, K. Johnson, and P. Steyger, Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis, Hearing Research, vol.204, issue.1-2, pp.156-169, 2005.
DOI : 10.1016/j.heares.2005.02.002

T. Nakagawa, H. Yamane, S. Shibata, and Y. Nakai, Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs, European Archives of Oto-rhino-laryngology, vol.92, issue.1, pp.9-14, 1997.
DOI : 10.1007/BF02630749

D. Newmeyer and S. Ferguson-miller, Mitochondria, Cell, vol.112, issue.4, pp.481-490, 2003.
DOI : 10.1016/S0092-8674(03)00116-8

T. Nicolson, The Genetics of Hearing and Balance in Zebrafish, Annual Review of Genetics, vol.39, issue.1, pp.9-22, 2005.
DOI : 10.1146/annurev.genet.39.073003.105049

T. Nicolson, A. Rusch, R. Friedrich, M. Granato, J. Ruppersberg et al., Genetic Analysis of Vertebrate Sensory Hair Cell Mechanosensation: the Zebrafish Circler Mutants, Neuron, vol.20, issue.2, pp.271-283, 1998.
DOI : 10.1016/S0896-6273(00)80455-9

T. Nicotera, B. Hu, and D. Henderson, The Caspase Pathway in Noise-Induced Apoptosis of the Chinchilla Cochlea, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.4, pp.466-477, 2003.
DOI : 10.1007/s10162-002-3038-2

J. Park and G. Cohen, Further observations of vestibular ototoxicity in the chick, American Journal of Otolaryngology, vol.5, issue.6, pp.387-393, 1984.
DOI : 10.1016/S0196-0709(84)80053-8

T. Peng and M. Jou, Mitochondrial Swelling and Generation of Reactive Oxygen Species Induced by Photoirradiation Are Heterogeneously Distributed, Annals of the New York Academy of Sciences, vol.39, issue.1, pp.112-122, 2004.
DOI : 10.1196/annals.1293.012

J. Pickles, Mutation in Mitochondrial DNA as a Cause of Presbyacusis, Audiology and Neurotology, vol.9, issue.1, pp.23-33, 2004.
DOI : 10.1159/000074184

J. Pickles and G. Rouse, Effects of streptomycin on development of the apical structures of hair cells in the chick basilar papilla, Hearing Research, vol.55, issue.2, pp.244-254, 1991.
DOI : 10.1016/0378-5955(91)90109-M

J. Pickles, S. Comis, and M. Osborne, The effect of chronic application of kanamycin on stereocilia and their tip links in hair cells of the guinea pig cochlea, Hearing Research, vol.29, issue.2-3, pp.237-244, 1987.
DOI : 10.1016/0378-5955(87)90170-5

U. Pirvola, L. Xing-qun, J. Virkkala, M. Saarma, C. Murakata et al., Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation, J Neurosci, vol.20, pp.43-50, 2000.

A. Popper and R. Fay, The Auditory Periphery in Fishes, pp.43-100, 1999.
DOI : 10.1007/978-1-4612-0533-3_3

K. Poss, M. Keating, and A. Nechiporuk, Tales of regeneration in zebrafish, Developmental Dynamics, vol.99, issue.2, pp.202-210, 2003.
DOI : 10.1002/dvdy.10220

E. Priuska and J. Schacht, Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex, Biochemical Pharmacology, vol.50, issue.11, pp.1749-1752, 1995.
DOI : 10.1016/0006-2952(95)02160-4

R. Pujol and J. Puel, Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings, Annals of the New York Academy of Sciences, vol.105, issue.1, pp.249-254, 1999.
DOI : 10.1111/j.1749-6632.1999.tb08646.x

D. Raible and G. Kruse, Organization of the lateral line system in embryonic zebrafish, The Journal of Comparative Neurology, vol.32, issue.2, pp.189-198, 2000.
DOI : 10.1002/(SICI)1096-9861(20000529)421:2<189::AID-CNE5>3.0.CO;2-K

Y. Raphael, B. Athey, Y. Wang, J. Hawkins, and . Jr, Structure of the reticular lamina and repair after noise injury, Rev Laryngol Otol Rhinol (Bord), vol.114, pp.171-175, 1993.

M. Recht, S. Douthwaite, and J. Puglisi, Basis for prokaryotic specificity of action of aminoglycoside antibiotics, The EMBO Journal, vol.18, issue.11, pp.3133-3138, 1999.
DOI : 10.1093/emboj/18.11.3133

M. Redd, L. Cooper, W. Wood, B. Stramer, and P. Martin, Wound healing and inflammation: embryos reveal the way to perfect repair, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.359, issue.1445, pp.777-784, 2004.
DOI : 10.1098/rstb.2004.1466

G. Richardson and I. Russell, Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity, Hearing Research, vol.53, issue.2, pp.293-311, 1991.
DOI : 10.1016/0378-5955(91)90062-E

L. Rybak and C. Whitworth, Ototoxicity: therapeutic opportunities, Drug Discovery Today, vol.10, issue.19, pp.1313-1321, 2005.
DOI : 10.1016/S1359-6446(05)03552-X

R. Sandoval and B. Molitoris, Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum, AJP: Renal Physiology, vol.286, issue.4, pp.617-624, 2004.
DOI : 10.1152/ajprenal.00130.2003

F. Santos, G. Macdonald, E. Rubel, and D. Raible, Lateral line hair cell maturation is a determinant of aminoglycoside susceptibility in zebrafish (Danio rerio), Hearing Research, vol.213, issue.1-2, pp.25-33, 2006.
DOI : 10.1016/j.heares.2005.12.009

J. Schacht, Antioxidant therapy attenuates aminoglycoside-induced hearing loss, Ann N Y Acad Sci, vol.884, pp.125-130, 1999.

S. Sha and J. Schacht, Stimulation of free radical formation by aminoglycoside antibiotics, Hearing Research, vol.128, issue.1-2, pp.112-118, 1999.
DOI : 10.1016/S0378-5955(98)00200-7

S. Sha, R. Taylor, A. Forge, and J. Schacht, Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals, Hearing Research, vol.155, issue.1-2, pp.1-8, 2001.
DOI : 10.1016/S0378-5955(01)00224-6

S. Sidi, E. Busch-nentwich, R. Friedrich, U. Schoenberger, and T. Nicolson, gemini Encodes a Zebrafish L-Type Calcium Channel That Localizes at Sensory Hair Cell Ribbon Synapses, Journal of Neuroscience, vol.24, issue.17, pp.4213-4223, 2004.
DOI : 10.1523/JNEUROSCI.0223-04.2004

H. Sobkowicz, B. Bereman, and J. Rose, Organotypic development of the organ of Corti in culture, Journal of Neurocytology, vol.22, issue.Suppl. 4, pp.543-572, 1975.
DOI : 10.1007/BF01351537

J. Song, H. Yan, and A. Popper, Damage and recovery of hair cells in fish canal (but not superficial) neuromasts after gentamicin exposure, Hearing Research, vol.91, issue.1-2, pp.63-71, 1995.
DOI : 10.1016/0378-5955(95)00170-0

P. Steyger, S. Peters, J. Rehling, A. Hordichok, and C. Dai, Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro, JARO - Journal of the Association for Research in Otolaryngology, vol.4, issue.4, pp.565-578, 2003.
DOI : 10.1007/s10162-003-4002-5

L. Stone, The development of lateral-line sense organs in amphibians observed in living and vital-stained preparations, The Journal of Comparative Neurology, vol.57, issue.3, pp.507-540, 1933.
DOI : 10.1002/cne.900570307

H. Sun, E. Hashino, D. Ding, and R. Salvi, Reversible and irreversible damage to cochlear afferent neurons by kainic acid excitotoxicity, The Journal of Comparative Neurology, vol.85, issue.2, pp.172-81, 2001.
DOI : 10.1002/1096-9861(20010205)430:2<172::AID-CNE1023>3.0.CO;2-W

M. Tachibana, H. Morioka, M. Machino, and O. Mizukoshi, Binding sites of an aminoglycoside in the cochlea examined by immunocytochemistry, Histochemistry, vol.81, issue.3-4, pp.237-240, 1985.
DOI : 10.1007/BF00953990

M. Takumida, D. Bagger-sjoback, Y. Harada, D. Lim, and J. Wersall, Sensory Hair Fusion and Glycocalyx Changes following Gentamicin Exposure in the Guinea Pig Vestibular Organs, Acta Oto-Laryngologica, vol.27, issue.1-2, pp.39-47, 1989.
DOI : 10.3109/00016488909127477

M. Takumida, M. Anniko, A. Shimizu, and H. Watanabe, Neuroprotection of Vestibular Sensory Cells from Gentamicin Ototoxicity Obtained Using Nitric Oxide Synthase Inhibitors, Reactive Oxygen Species Scavengers, Brain-derived Neurotrophic Factors and Calpain Inhibitors, Acta Oto-Laryngologica, vol.18, issue.1, pp.8-13, 2003.
DOI : 10.1080/00016480252775661

T. Ba-huy, P. Bernard, P. Schacht, and J. , Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs., Journal of Clinical Investigation, vol.77, issue.5, pp.1492-1500, 1986.
DOI : 10.1172/JCI112463

P. Vago, G. Humbert, and M. Lenoir, Amikacin intoxication induces apoptosis and cell proliferation in rat organ of Corti, NeuroReport, vol.9, issue.3, pp.431-436, 1998.
DOI : 10.1097/00001756-199802160-00014

S. Vakulenko and S. Mobashery, Versatility of Aminoglycosides and Prospects for Their Future, Clinical Microbiology Reviews, vol.16, issue.3, pp.430-450, 2003.
DOI : 10.1128/CMR.16.3.430-450.2003

M. Vander-heiden, N. Chandel, E. Williamson, P. Schumacker, and C. Thompson, Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria, Cell, vol.91, issue.5, pp.627-637, 1997.
DOI : 10.1016/S0092-8674(00)80450-X

Q. Vicens and E. Westhof, Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: An analysis of x-ray crystal structures, Biopolymers, vol.419, issue.1, pp.42-57, 2003.
DOI : 10.1002/bip.10414

N. Wagner, P. Caye-thomasen, G. Laurell, D. Bagger-sjoback, and J. Thomsen, Cochlear hair cell loss in single-dose versus continuous round window administration of gentamicin, Acta Oto-Laryngologica, vol.117, issue.4, pp.340-345, 2005.
DOI : 10.1080/00016480510026881

D. Wallace, A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine, Annual Review of Genetics, vol.39, issue.1, pp.357-407, 2005.
DOI : 10.1146/annurev.genet.39.110304.095751

J. Wang, T. Van-de-water, C. Bonny, F. De-ribaupierre, J. Puel et al., A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss, J Neurosci, vol.23, pp.8596-8607, 2003.

J. Webb and J. Shirey, Postembryonic development of the cranial lateral line canals and neuromasts in zebrafish, Developmental Dynamics, vol.233, issue.3, pp.370-385, 2003.
DOI : 10.1002/dvdy.10385

M. Weil, M. Jacobson, H. Coles, T. Davies, R. Gardner et al., Constitutive expression of the machinery for programmed cell death, The Journal of Cell Biology, vol.133, issue.5, pp.1053-1059, 1996.
DOI : 10.1083/jcb.133.5.1053

P. Weisleder and E. Rubel, Hair cell regeneration in the avian vestibular epithelium, Experimental Neurology, vol.115, issue.1, pp.2-6, 1992.
DOI : 10.1016/0014-4886(92)90211-8

J. Wersaell and A. Flock, Functional Anatomy of the Vestibular and Lateral Line Organs, Contrib Sens Physiol, vol.14, pp.39-61, 1965.
DOI : 10.1016/B978-1-4831-6746-6.50007-9

J. Wersall, J. Hawkins, and . Jr, The Vestibular Sensory Epithelia in the Cat Labyrinth and Their Reactions in Chronic Streptomycin Intoxication, Acta Oto-Laryngologica, vol.57, issue.126, pp.1-23, 1962.
DOI : 10.3109/00016486209126917

M. Westerfield, The zebrafish book, 1995.

J. Wilhelm, J. Jessop, and S. Pettitt, Aminoglycoside antibiotics and eukaryotic protein synthesis: stimulation of errors in the translation of natural messengers in extracts of cultured human cells, Biochemistry, vol.17, issue.7, pp.1149-1153, 1978.
DOI : 10.1021/bi00600a002

J. Williams and N. Holder, Cell turnover in neuromasts of zebrafish larvae, Hearing Research, vol.143, issue.1-2, pp.171-181, 2000.
DOI : 10.1016/S0378-5955(00)00039-3

S. Williams, H. Zenner, and J. Schacht, Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells, Hearing Research, vol.30, issue.1, pp.11-18, 1987.
DOI : 10.1016/0378-5955(87)90177-8

Q. Yan, X. Li, G. Faye, and M. Guan, Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA, Journal of Biological Chemistry, vol.280, issue.32, pp.29151-29157, 2005.
DOI : 10.1074/jbc.M504247200

J. Ylikoski, Guinea-Pig Hair Cell Pathology from Ototoxic Antibiotics, Acta Oto-Laryngologica, vol.78, issue.sup326, pp.5-22, 1974.
DOI : 10.3109/00016487409129729

J. Ylikoski, L. Xing-qun, J. Virkkala, and U. Pirvola, Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death, Hearing Research, vol.166, issue.1-2, pp.33-43, 2002.
DOI : 10.1016/S0378-5955(01)00388-4

H. Zhao, R. Li, Q. Wang, Q. Yan, J. Deng et al., Maternally Inherited Aminoglycoside-Induced and Nonsyndromic Deafness Is Associated with the Novel C1494T Mutation in the Mitochondrial 12S rRNA Gene in a Large Chinese Family, The American Journal of Human Genetics, vol.74, issue.1, pp.139-152, 2004.
DOI : 10.1086/381133