Unraveling ICAP-1 function: toward a new direction?

Daniel Bouvard 1, 2, * Angélique Millon-Fremillon 1, 2 Sandra Dupe-Manet 1, 2 Marc Block 3 Corinne Albiges-Rizo 3
* Auteur correspondant
3 INSERM U823, équipe 1 (DySAD)
LEDAC - Laboratoire d'études de la différenciation et de l'adhérence cellulaires, DySAD - Dynamique des systèmes d'adhérence et différenciation
Abstract : Cell adhesion to either the extracellular matrix (ECM) or to neighboring cells is of critical importance during both physiological and pathological situations. Integrins are a large family of cell adhesion receptors composed of two non-covalently linked alpha and beta subunits. They have a well-identified dual function of mediating both firm adhesion and signaling. The short cytoplasmic domain of integrin can interact with cytoplasmic proteins that are either shared by several different integrins or specific for one type of integrin. Integrin cytoplasmic domain-associated protein-1 (ICAP-1) is a small cytoplasmic protein that specifically interacts with the beta1 integrin subunit. In this review we will discuss recent findings on ICAP-1, not only at the structural and functional level, but also its possible interconnection in other signaling pathways such as those that control cell proliferation.
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Article dans une revue
European Journal of Cell Biology, Elsevier, 2006, 85 (3-4), pp.275-282
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Soumis le : lundi 6 août 2007 - 10:09:40
Dernière modification le : jeudi 11 janvier 2018 - 06:26:55
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  • HAL Id : inserm-00166352, version 1
  • PUBMED : 16546571

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Daniel Bouvard, Angélique Millon-Fremillon, Sandra Dupe-Manet, Marc Block, Corinne Albiges-Rizo. Unraveling ICAP-1 function: toward a new direction?. European Journal of Cell Biology, Elsevier, 2006, 85 (3-4), pp.275-282. 〈inserm-00166352〉

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